Van Der Brug M - Search Results

1

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability.

Beilina A, Van Der Brug M, Ahmad R, Kesavapany S, Miller DW, Petsko GA, Cookson MR. Beilina A, et al. Among authors: van der brug m. Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5703-8. doi: 10.1073/pnas.0500617102. Epub 2005 Apr 11. Proc Natl Acad Sci U S A. 2005. PMID: 15824318 Free PMC article.

2

Effects of DJ-1 mutations and polymorphisms on protein stability and subcellular localization.

Blackinton J, Ahmad R, Miller DW, van der Brug MP, Canet-Avilés RM, Hague SM, Kaleem M, Cookson MR. Blackinton J, et al. Among authors: van der brug mp. Brain Res Mol Brain Res. 2005 Mar 24;134(1):76-83. doi: 10.1016/j.molbrainres.2004.09.004. Brain Res Mol Brain Res. 2005. PMID: 15790532

3

RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways.

van der Brug MP, Blackinton J, Chandran J, Hao LY, Lal A, Mazan-Mamczarz K, Martindale J, Xie C, Ahmad R, Thomas KJ, Beilina A, Gibbs JR, Ding J, Myers AJ, Zhan M, Cai H, Bonini NM, Gorospe M, Cookson MR. van der Brug MP, et al. Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10244-9. doi: 10.1073/pnas.0708518105. Epub 2008 Jul 14. Proc Natl Acad Sci U S A. 2008. PMID: 18626009 Free PMC article.

4

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.

Beilina A, Rudenko IN, Kaganovich A, Civiero L, Chau H, Kalia SK, Kalia LV, Lobbestael E, Chia R, Ndukwe K, Ding J, Nalls MA; International Parkinson’s Disease Genomics Consortium; North American Brain Expression Consortium; Olszewski M, Hauser DN, Kumaran R, Lozano AM, Baekelandt V, Greene LE, Taymans JM, Greggio E, Cookson MR. Beilina A, et al. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2626-31. doi: 10.1073/pnas.1318306111. Epub 2014 Feb 7. Proc Natl Acad Sci U S A. 2014. PMID: 24510904 Free PMC article.

5

Cell systems and the toxic mechanism(s) of alpha-synuclein.

Cookson MR, van der Brug M. Cookson MR, et al. Among authors: van der brug m. Exp Neurol. 2008 Jan;209(1):5-11. doi: 10.1016/j.expneurol.2007.05.022. Epub 2007 Jun 4. Exp Neurol. 2008. PMID: 17603039 Free PMC article. Review.

6

Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.

Sandebring A, Thomas KJ, Beilina A, van der Brug M, Cleland MM, Ahmad R, Miller DW, Zambrano I, Cowburn RF, Behbahani H, Cedazo-Mínguez A, Cookson MR. Sandebring A, et al. Among authors: van der brug m. PLoS One. 2009 May 27;4(5):e5701. doi: 10.1371/journal.pone.0005701. PLoS One. 2009. PMID: 19492085 Free PMC article.

7

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.

Thomas KJ, McCoy MK, Blackinton J, Beilina A, van der Brug M, Sandebring A, Miller D, Maric D, Cedazo-Minguez A, Cookson MR. Thomas KJ, et al. Among authors: van der brug m. Hum Mol Genet. 2011 Jan 1;20(1):40-50. doi: 10.1093/hmg/ddq430. Epub 2010 Oct 11. Hum Mol Genet. 2011. PMID: 20940149 Free PMC article.

8

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.

Greggio E, Jain S, Kingsbury A, Bandopadhyay R, Lewis P, Kaganovich A, van der Brug MP, Beilina A, Blackinton J, Thomas KJ, Ahmad R, Miller DW, Kesavapany S, Singleton A, Lees A, Harvey RJ, Harvey K, Cookson MR. Greggio E, et al. Neurobiol Dis. 2006 Aug;23(2):329-41. doi: 10.1016/j.nbd.2006.04.001. Epub 2006 Jun 5. Neurobiol Dis. 2006. PMID: 16750377

9

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

Greggio E, Lewis PA, van der Brug MP, Ahmad R, Kaganovich A, Ding J, Beilina A, Baker AK, Cookson MR. Greggio E, et al. J Neurochem. 2007 Jul;102(1):93-102. doi: 10.1111/j.1471-4159.2007.04523.x. Epub 2007 Mar 29. J Neurochem. 2007. PMID: 17394548 Free article.

10

Post-transcriptional regulation of mRNA associated with DJ-1 in sporadic Parkinson disease.

Blackinton J, Kumaran R, van der Brug MP, Ahmad R, Olson L, Galter D, Lees A, Bandopadhyay R, Cookson MR. Blackinton J, et al. Neurosci Lett. 2009 Mar 6;452(1):8-11. doi: 10.1016/j.neulet.2008.12.053. Epub 2009 Jan 6. Neurosci Lett. 2009. PMID: 19146923 Free PMC article.

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