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Purified Argonaute2 and an siRNA form recombinant human RISC.
Rivas FV, Tolia NH, Song JJ, Aragon JP, Liu J, Hannon GJ, Joshua-Tor L. Rivas FV, et al. Among authors: liu j. Nat Struct Mol Biol. 2005 Apr;12(4):340-9. doi: 10.1038/nsmb918. Epub 2005 Mar 30. Nat Struct Mol Biol. 2005. PMID: 15800637
Argonaute2 is the catalytic engine of mammalian RNAi.
Liu J, Carmell MA, Rivas FV, Marsden CG, Thomson JM, Song JJ, Hammond SM, Joshua-Tor L, Hannon GJ. Liu J, et al. Science. 2004 Sep 3;305(5689):1437-41. doi: 10.1126/science.1102513. Epub 2004 Jul 29. Science. 2004. PMID: 15284456
A role for the P-body component GW182 in microRNA function.
Liu J, Rivas FV, Wohlschlegel J, Yates JR 3rd, Parker R, Hannon GJ. Liu J, et al. Nat Cell Biol. 2005 Dec;7(12):1261-6. doi: 10.1038/ncb1333. Epub 2005 Nov 13. Nat Cell Biol. 2005. PMID: 16284623 Free PMC article.
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