Shibata S - Search Results

1

Loss of lysophospholipase 3 increases atherosclerosis in apolipoprotein E-deficient mice.

Taniyama Y, Fuse H, Satomi T, Tozawa R, Yasuhara Y, Shimakawa K, Shibata S, Hattori M, Nakata M, Taketomi S. Taniyama Y, et al. Among authors: shibata s. Biochem Biophys Res Commun. 2005 Apr 29;330(1):104-10. doi: 10.1016/j.bbrc.2005.02.126. Biochem Biophys Res Commun. 2005. PMID: 15781238

2

Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.

Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M. Taniyama Y, et al. Among authors: shibata s. Biochem Biophys Res Commun. 1999 Apr 2;257(1):50-6. doi: 10.1006/bbrc.1999.0411. Biochem Biophys Res Commun. 1999. PMID: 10092508

3

Antitumor activity of a novel and orally available inhibitor of serine palmitoyltransferase.

Yaguchi M, Shibata S, Satomi Y, Hirayama M, Adachi R, Asano Y, Kojima T, Hirata Y, Mizutani A, Kiba A, Sagiya Y. Yaguchi M, et al. Among authors: shibata s. Biochem Biophys Res Commun. 2017 Mar 11;484(3):493-500. doi: 10.1016/j.bbrc.2017.01.075. Epub 2017 Jan 17. Biochem Biophys Res Commun. 2017. PMID: 28108287

4

CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens.

Ishii T, Okai T, Iwatani-Yoshihara M, Mochizuki M, Unno S, Kuno M, Yoshikawa M, Shibata S, Nakakariya M, Yogo T, Kawamoto T. Ishii T, et al. Among authors: shibata s. Sci Rep. 2017 Oct 12;7(1):13000. doi: 10.1038/s41598-017-12513-1. Sci Rep. 2017. PMID: 29026104 Free PMC article.

5

Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors.

Ohashi T, Oguro Y, Tanaka T, Shiokawa Z, Shibata S, Sato Y, Yamakawa H, Hattori H, Yamamoto Y, Kondo S, Miyamoto M, Tojo H, Baba A, Sasaki S. Ohashi T, et al. Among authors: shibata s. Bioorg Med Chem. 2012 Sep 15;20(18):5496-506. doi: 10.1016/j.bmc.2012.07.039. Epub 2012 Jul 31. Bioorg Med Chem. 2012. PMID: 22910224

6

Pharmacokinetic and pharmacodynamic modeling of hedgehog inhibitor TAK-441 for the inhibition of Gli1 messenger RNA expression and antitumor efficacy in xenografted tumor model mice.

Kogame A, Tagawa Y, Shibata S, Tojo H, Miyamoto M, Tohyama K, Kondo T, Prakash S, Shyu WC, Asahi S. Kogame A, et al. Among authors: shibata s. Drug Metab Dispos. 2013 Apr;41(4):727-34. doi: 10.1124/dmd.112.049650. Epub 2013 Jan 8. Drug Metab Dispos. 2013. PMID: 23298863

7

Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor.

Iwai K, Nambu T, Dairiki R, Ohori M, Yu J, Burke K, Gotou M, Yamamoto Y, Ebara S, Shibata S, Hibino R, Nishizawa S, Miyazaki T, Homma M, Oguro Y, Imada T, Cho N, Uchiyama N, Kogame A, Takeuchi T, Kurasawa O, Yamanaka K, Niu H, Ohashi A. Iwai K, et al. Among authors: shibata s. Sci Adv. 2019 May 22;5(5):eaav3660. doi: 10.1126/sciadv.aav3660. eCollection 2019 May. Sci Adv. 2019. PMID: 31131319 Free PMC article.

8

Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.

Ohashi T, Oguro Y, Tanaka T, Shiokawa Z, Tanaka Y, Shibata S, Sato Y, Yamakawa H, Hattori H, Yamamoto Y, Kondo S, Miyamoto M, Nishihara M, Ishimura Y, Tojo H, Baba A, Sasaki S. Ohashi T, et al. Among authors: shibata s. Bioorg Med Chem. 2012 Sep 15;20(18):5507-17. doi: 10.1016/j.bmc.2012.07.034. Epub 2012 Jul 27. Bioorg Med Chem. 2012. PMID: 22898254

9

Ameliorative effect of phosphodiesterase 4 and 5 inhibitors in deoxycorticosterone acetate-salt hypertensive uni-nephrectomized KKA^y mice.

Nio Y, Ookawara M, Yamasaki M, Hanauer G, Tohyama K, Shibata S, Sano T, Shimizu F, Anayama H, Hazama M, Matsuo T. Nio Y, et al. Among authors: shibata s. FASEB J. 2020 Nov;34(11):14997-15014. doi: 10.1096/fj.202001084R. Epub 2020 Sep 16. FASEB J. 2020. PMID: 32939821

10

Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents.

Kojima T, Asano Y, Kurasawa O, Hirata Y, Iwamura N, Wong TT, Saito B, Tanaka Y, Arai R, Yonemori K, Miyamoto Y, Sagiya Y, Yaguchi M, Shibata S, Mizutani A, Sano O, Adachi R, Satomi Y, Hirayama M, Aoyama K, Hiura Y, Kiba A, Kitamura S, Imamura S. Kojima T, et al. Among authors: shibata s. Bioorg Med Chem. 2018 May 15;26(9):2452-2465. doi: 10.1016/j.bmc.2018.04.008. Epub 2018 Apr 4. Bioorg Med Chem. 2018. PMID: 29669694

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