Barbosa J - Search Results

1

Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships.

Kempson J, Pitts WJ, Barbosa J, Guo J, Omotoso O, Watson A, Stebbins K, Starling GC, Dodd JH, Barrish JC, Felix R, Fischer K. Kempson J, et al. Among authors: barbosa j. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1829-33. doi: 10.1016/j.bmcl.2005.02.025. Bioorg Med Chem Lett. 2005. PMID: 15780616

2

Identification of purine inhibitors of phosphodiesterase 7 (PDE7).

Pitts WJ, Vaccaro W, Huynh T, Leftheris K, Roberge JY, Barbosa J, Guo J, Brown B, Watson A, Donaldson K, Starling GC, Kiener PA, Poss MA, Dodd JH, Barrish JC. Pitts WJ, et al. Among authors: barbosa j. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2955-8. doi: 10.1016/j.bmcl.2004.03.021. Bioorg Med Chem Lett. 2004. PMID: 15125967

3

Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation.

Guo J, Watson A, Kempson J, Carlsen M, Barbosa J, Stebbins K, Lee D, Dodd J, Nadler SG, McKinnon M, Barrish J, Pitts WJ. Guo J, et al. Among authors: barbosa j. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1935-8. doi: 10.1016/j.bmcl.2009.02.060. Epub 2009 Feb 21. Bioorg Med Chem Lett. 2009. PMID: 19272774

4

Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13).

Kim SH, Pudzianowski AT, Leavitt KJ, Barbosa J, McDonnell PA, Metzler WJ, Rankin BM, Liu R, Vaccaro W, Pitts W. Kim SH, et al. Among authors: barbosa j. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1101-6. doi: 10.1016/j.bmcl.2004.12.016. Bioorg Med Chem Lett. 2005. PMID: 15686921

5

Design, synthesis, and in vivo activity of novel inhibitors of delta-5 desaturase for the treatment of metabolic syndrome.

Baugh SD, Pabba PK, Barbosa J, Coulter E, Desai U, Gay JP, Gopinathan S, Han Q, Hari R, Kimball SD, Nguyen HV, Ni CY, Powell DR, Smith A, Terranova KM, Wilson A, Yu XC, Lombardo VK. Baugh SD, et al. Among authors: barbosa j. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3836-9. doi: 10.1016/j.bmcl.2015.07.066. Epub 2015 Jul 26. Bioorg Med Chem Lett. 2015. PMID: 26235947

6

4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase.

Han Q, Pabba PK, Barbosa J, Mabon R, Healy JP, Gardyan MW, Terranova KM, Brommage R, Thompson AY, Schmidt JM, Wilson AG, Xu X, Tarver JE Jr, Carson KG. Han Q, et al. Among authors: barbosa j. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1184-7. doi: 10.1016/j.bmcl.2016.01.038. Epub 2016 Jan 18. Bioorg Med Chem Lett. 2016. PMID: 26821819

7

Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase.

Tarver JE Jr, Pabba PK, Barbosa J, Han Q, Gardyan MW, Brommage R, Thompson AY, Schmidt JM, Wilson AGE, He W, Lombardo VK, Carson KG. Tarver JE Jr, et al. Among authors: barbosa j. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1525-1528. doi: 10.1016/j.bmcl.2016.02.021. Epub 2016 Feb 10. Bioorg Med Chem Lett. 2016. PMID: 26897593

8

Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach.

Smith RA, Barbosa J, Blum CL, Bobko MA, Caringal YV, Dally R, Johnson JS, Katz ME, Kennure N, Kingery-Wood J, Lee W, Lowinger TB, Lyons J, Marsh V, Rogers DH, Swartz S, Walling T, Wild H. Smith RA, et al. Among authors: barbosa j. Bioorg Med Chem Lett. 2001 Oct 22;11(20):2775-8. doi: 10.1016/s0960-894x(01)00571-6. Bioorg Med Chem Lett. 2001. PMID: 11591521

9

Novel inhibitors of the high-affinity L-proline transporter as potential therapeutic agents for the treatment of cognitive disorders.

Zipp GG, Barbosa J, Green MA, Terranova KM, Fink C, Yu XC, Nouraldeen A, Wilson A, Savelieva K, Lanthorn TH, David Kimball S. Zipp GG, et al. Among authors: barbosa j. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3886-90. doi: 10.1016/j.bmcl.2014.06.049. Epub 2014 Jul 1. Bioorg Med Chem Lett. 2014. PMID: 25037917

10

Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors.

Smith AB 3rd, Cantin LD, Pasternak A, Guise-Zawacki L, Yao W, Charnley AK, Barbosa J, Sprengeler PA, Hirschmann R, Munshi S, Olsen DB, Schleif WA, Kuo LC. Smith AB 3rd, et al. Among authors: barbosa j. J Med Chem. 2003 May 8;46(10):1831-44. doi: 10.1021/jm0204587. J Med Chem. 2003. PMID: 12723947

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