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824 results

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Page 1
Synthesis and biological evaluation of 1,2,4-triazinylphenylalkylthiazolecarboxylic acid esters as cytokine-inhibiting antedrugs with strong bronchodilating effects in an animal model of asthma.
Freyne EJ, Lacrampe JF, Deroose F, Boeckx GM, Willems M, Embrechts W, Coesemans E, Willems JJ, Fortin JM, Ligney Y, Dillen LL, Cools WF, Goossens J, Corens D, De Groot A, Van Wauwe JP. Freyne EJ, et al. Among authors: de groot a. J Med Chem. 2005 Mar 24;48(6):2167-75. doi: 10.1021/jm049479m. J Med Chem. 2005. PMID: 15771459
Synthesis and in vitro and in vivo structure-activity relationships of novel antifungal triazoles for dermatology.
Meerpoel L, Backx LJ, Van der Veken LJ, Heeres J, Corens D, De Groot A, Odds FC, Van Gerven F, Woestenborghs FA, Van Breda A, Oris M, van Dorsselaer P, Willemsens GH, Vermuyten KJ, Marichal PJ, Vanden Bossche HF, Ausma J, Borgers M. Meerpoel L, et al. Among authors: de groot a. J Med Chem. 2005 Mar 24;48(6):2184-93. doi: 10.1021/jm0494772. J Med Chem. 2005. PMID: 15771461
Synthesis and in vitro and in vivo antifungal activity of the hydroxy metabolites of saperconazole.
Meerpoel L, Heeres J, Backx LJ, Van der Veken LJ, Hendrickx R, Corens D, De Groot A, Leurs S, Van der Eycken L, Weerts J, Luyts P, Van Gerven F, Woestenborghs FA, Van Breda A, Oris M, van Dorsselaer P, Willemsens GH, Bellens D, Marichal PJ, Vanden Bossche HF, Odds FC. Meerpoel L, et al. Among authors: de groot a. ChemMedChem. 2010 May 3;5(5):757-69. doi: 10.1002/cmdc.201000040. ChemMedChem. 2010. PMID: 20379992
Automated high-throughput RP-HPLC-MS and SFC-MS analytical and purification platforms to support drug discovery.
Chen K, Dores-Sousa JL, Fontana A, Grosanu C, McAllister HM, Bai G, Bartkowiak K, Cañellas S, Corens D, De Groot A, Nevarez J, Serrano M, Raeymaekers K, Rodriguez R, Van Eynde L, Zhou R, Shi Z. Chen K, et al. Among authors: de groot a. J Chromatogr A. 2025 Feb 8;1742:465648. doi: 10.1016/j.chroma.2024.465648. Epub 2024 Dec 31. J Chromatogr A. 2025. PMID: 39793447
Synthesis and evaluation of novel HCV replication inhibitors.
McGowan DC, Khamlichi MD, De Groot A, Pauwels F, Delouvroy F, Van Emelen K, Simmen K, Raboisson P. McGowan DC, et al. Among authors: de groot a. Mol Divers. 2017 May;21(2):475-481. doi: 10.1007/s11030-017-9733-z. Epub 2017 Mar 14. Mol Divers. 2017. PMID: 28293834
Fragment Binding to β-Secretase 1 without Catalytic Aspartate Interactions Identified via Orthogonal Screening Approaches.
Rombouts FJR, Alexander R, Cleiren E, De Groot A, Carpentier M, Dijkmans J, Fierens K, Masure S, Moechars D, Palomino-Schätzlein M, Pineda-Lucena A, Trabanco AA, Van Glabbeek D, Vos A, Tresadern G. Rombouts FJR, et al. Among authors: de groot a. ACS Omega. 2017 Feb 28;2(2):685-697. doi: 10.1021/acsomega.6b00482. Epub 2017 Feb 24. ACS Omega. 2017. PMID: 28626832 Free PMC article.
Safety and immunogenicity of Ad26.COV2.S in adolescents: Phase 2 randomized clinical trial.
Tica J, Rezelj VV, Baron B, van Paassen V, Zaidman J, Fairlie L, Scheper G, Le Gars M, Struyf F, Douoguih M, Ruiz-Guiñazú J; COV3006 study group; COV3006 Study Group Collaborators. Tica J, et al. Hum Vaccin Immunother. 2025 Dec;21(1):2450120. doi: 10.1080/21645515.2025.2450120. Epub 2025 Jan 27. Hum Vaccin Immunother. 2025. PMID: 39868766 Free PMC article. Clinical Trial.
824 results