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Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine-3-monooxygenase with microglial decline.
Hasegawa M, Kunisawa K, Wulaer B, Kubota H, Kurahashi H, Sakata T, Ando H, Fujigaki S, Fujigaki H, Yamamoto Y, Nagai T, Saito K, Nabeshima T, Mouri A. Hasegawa M, et al. Among authors: nabeshima t. Br J Pharmacol. 2024 Dec 10. doi: 10.1111/bph.17407. Online ahead of print. Br J Pharmacol. 2024. PMID: 39658392
Adolescent social isolation decreases colonic goblet cells and impairs spatial cognition through the reduction of cystine.
Tanabe M, Kunisawa K, Saito I, Kosuge A, Tezuka H, Kawai T, Kon Y, Yoshidomi K, Kagami A, Hasegawa M, Kubota H, Ojika H, Fujii T, Tochio T, Hirooka Y, Saito K, Nabeshima T, Mouri A. Tanabe M, et al. Among authors: nabeshima t. Mol Psychiatry. 2024 Nov 29. doi: 10.1038/s41380-024-02826-9. Online ahead of print. Mol Psychiatry. 2024. PMID: 39613916
Maternal immune activation induces neurodevelopmental impairments of adult offspring through alterations in tryptophane-kynurenine pathway in the placenta.
Hasegawa M, Niijima M, Kunisawa K, Teshigawara T, Kubota H, Fujigaki S, Fujigaki H, Yamamoto Y, Kim HC, Saito K, Nabeshima T, Mouri A. Hasegawa M, et al. Among authors: nabeshima t. Biochem Biophys Res Commun. 2024 Dec 10;737:150922. doi: 10.1016/j.bbrc.2024.150922. Epub 2024 Oct 28. Biochem Biophys Res Commun. 2024. PMID: 39486137
Autism spectrum disorder-like behaviors induced by hyper-glutamatergic NMDA receptor signaling through hypo-serotonergic 5-HT1A receptor signaling in the prefrontal cortex in mice exposed to prenatal valproic acid.
Kurahashi H, Kunisawa K, Tanaka KF, Kubota H, Hasegawa M, Miyachi M, Moriya Y, Hasegawa Y, Nagai T, Saito K, Nabeshima T, Mouri A. Kurahashi H, et al. Among authors: nabeshima t. Neuropsychopharmacology. 2024 Oct 11. doi: 10.1038/s41386-024-02004-z. Online ahead of print. Neuropsychopharmacology. 2024. PMID: 39394255
1,087 results