Roehrig S - Search Results

1

In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939--an oral, direct Factor Xa inhibitor.

Perzborn E, Strassburger J, Wilmen A, Pohlmann J, Roehrig S, Schlemmer KH, Straub A. Perzborn E, et al. Among authors: roehrig s. J Thromb Haemost. 2005 Mar;3(3):514-21. doi: 10.1111/j.1538-7836.2005.01166.x. J Thromb Haemost. 2005. PMID: 15748242 Free article.

2

Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor.

Roehrig S, Straub A, Pohlmann J, Lampe T, Pernerstorfer J, Schlemmer KH, Reinemer P, Perzborn E. Roehrig S, et al. J Med Chem. 2005 Sep 22;48(19):5900-8. doi: 10.1021/jm050101d. J Med Chem. 2005. PMID: 16161994

3

Rivaroxaban: a new oral factor Xa inhibitor.

Perzborn E, Roehrig S, Straub A, Kubitza D, Mueck W, Laux V. Perzborn E, et al. Among authors: roehrig s. Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):376-81. doi: 10.1161/ATVBAHA.110.202978. Epub 2010 Feb 5. Arterioscler Thromb Vasc Biol. 2010. PMID: 20139357 Review.

4

Entering the era of non-basic p1 site groups: discovery of Xarelto (Rivaroxaban).

Straub A, Roehrig S, Hillisch A. Straub A, et al. Among authors: roehrig s. Curr Top Med Chem. 2010;10(3):257-69. doi: 10.2174/156802610790725506. Curr Top Med Chem. 2010. PMID: 20166954 Review.

5

The discovery and development of rivaroxaban, an oral, direct factor Xa inhibitor.

Perzborn E, Roehrig S, Straub A, Kubitza D, Misselwitz F. Perzborn E, et al. Among authors: roehrig s. Nat Rev Drug Discov. 2011 Jan;10(1):61-75. doi: 10.1038/nrd3185. Epub 2010 Dec 17. Nat Rev Drug Discov. 2011. PMID: 21164526 Review.

6

Oral, direct thrombin and factor Xa inhibitors: the replacement for warfarin, leeches, and pig intestines?

Straub A, Roehrig S, Hillisch A. Straub A, et al. Among authors: roehrig s. Angew Chem Int Ed Engl. 2011 May 9;50(20):4574-90. doi: 10.1002/anie.201004575. Epub 2011 Apr 29. Angew Chem Int Ed Engl. 2011. PMID: 21538731 Review.

7

Pharmacological profile of asundexian, a novel, orally bioavailable inhibitor of factor XIa.

Heitmeier S, Visser M, Tersteegen A, Dietze-Torres J, Glunz J, Gerdes C, Laux V, Stampfuss J, Roehrig S. Heitmeier S, et al. Among authors: roehrig s. J Thromb Haemost. 2022 Jun;20(6):1400-1411. doi: 10.1111/jth.15700. Epub 2022 Mar 25. J Thromb Haemost. 2022. PMID: 35289054 Free PMC article.

8

Design and Preclinical Characterization Program toward Asundexian (BAY 2433334), an Oral Factor XIa Inhibitor for the Prevention and Treatment of Thromboembolic Disorders.

Roehrig S, Ackerstaff J, Jiménez Núñez E, Teller H, Ellerbrock P, Meier K, Heitmeier S, Tersteegen A, Stampfuss J, Lang D, Schlemmer KH, Schaefer M, Gericke KM, Kinzel T, Meibom D, Schmidt M, Gerdes C, Follmann M, Hillisch A. Roehrig S, et al. J Med Chem. 2023 Sep 14;66(17):12203-12224. doi: 10.1021/acs.jmedchem.3c00795. Epub 2023 Sep 5. J Med Chem. 2023. PMID: 37669040 Free PMC article.

9

Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics.

Hillisch A, Gericke KM, Allerheiligen S, Roehrig S, Schaefer M, Tersteegen A, Schulz S, Lienau P, Gnoth M, Puetter V, Hillig RC, Heitmeier S. Hillisch A, et al. Among authors: roehrig s. J Med Chem. 2020 Nov 12;63(21):12574-12594. doi: 10.1021/acs.jmedchem.0c01035. Epub 2020 Oct 27. J Med Chem. 2020. PMID: 33108181 Free article.

10

Gabel-Pfisterer A, Böhringer D, Agostini H; Feuerwerks-Verletzungen-Studiengruppe. Gabel-Pfisterer A, et al. Ophthalmologie. 2022 Dec;119(12):1257-1266. doi: 10.1007/s00347-022-01778-1. Epub 2022 Nov 30. Ophthalmologie. 2022. PMID: 36449087 Free PMC article. German.

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