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A novel crystallization-induced diastereomeric transformation based on a reversible carbon-sulfur bond formation. Application to the synthesis of a gamma-secretase inhibitor.
Davies AJ, Scott JP, Bishop BC, Brands KM, Brewer SE, Dasilva JO, Dormer PG, Dolling UH, Gibb AD, Hammond DC, Lieberman DR, Palucki M, Payack JF. Davies AJ, et al. Among authors: bishop bc. J Org Chem. 2007 Jun 22;72(13):4864-71. doi: 10.1021/jo0705925. Epub 2007 May 24. J Org Chem. 2007. PMID: 17521199
Highly Diastereoselective Synthesis of a HCV NS5B Nucleoside Polymerase Inhibitor.
Zhong YL, Cleator E, Liu Z, Yin J, Morris WJ, Alam M, Bishop B, Dumas AM, Edwards J, Goodyear A, Mullens P, Song ZJ, Shevlin M, Thaisrivongs DA, Li H, Sherer EC, Cohen RD, Yin J, Tan L, Yasuda N, Limanto J, Davies A, Campos KR. Zhong YL, et al. J Org Chem. 2019 Apr 19;84(8):4780-4795. doi: 10.1021/acs.joc.8b02500. Epub 2018 Dec 10. J Org Chem. 2019. PMID: 30475616
Asymmetric hydrogenation of protected allylic amines.
Steinhuebel DP, Krska SW, Alorati A, Baxter JM, Belyk K, Bishop B, Palucki M, Sun Y, Davies IW. Steinhuebel DP, et al. Org Lett. 2010 Sep 17;12(18):4201-3. doi: 10.1021/ol101804e. Org Lett. 2010. PMID: 20735080