Sarbassov DD - Search Results

1

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Sarbassov DD, et al. Science. 2005 Feb 18;307(5712):1098-101. doi: 10.1126/science.1106148. Science. 2005. PMID: 15718470

2

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Kim DH, et al. Among authors: sarbassov dd. Cell. 2002 Jul 26;110(2):163-75. doi: 10.1016/s0092-8674(02)00808-5. Cell. 2002. PMID: 12150925 Free article.

3

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.

Kim DH, Sarbassov DD, Ali SM, Latek RR, Guntur KV, Erdjument-Bromage H, Tempst P, Sabatini DM. Kim DH, et al. Among authors: sarbassov dd. Mol Cell. 2003 Apr;11(4):895-904. doi: 10.1016/s1097-2765(03)00114-x. Mol Cell. 2003. PMID: 12718876 Free article.

4

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.

Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Sarbassov DD, et al. Curr Biol. 2004 Jul 27;14(14):1296-302. doi: 10.1016/j.cub.2004.06.054. Curr Biol. 2004. PMID: 15268862 Free article.

5

Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.

Boulbes D, Chen CH, Shaikenov T, Agarwal NK, Peterson TR, Addona TA, Keshishian H, Carr SA, Magnuson MA, Sabatini DM, Sarbassov dos D. Boulbes D, et al. Mol Cancer Res. 2010 Jun;8(6):896-906. doi: 10.1158/1541-7786.MCR-09-0409. Epub 2010 May 25. Mol Cancer Res. 2010. PMID: 20501647 Free PMC article.

6

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

Zeng Z, Sarbassov dos D, Samudio IJ, Yee KW, Munsell MF, Ellen Jackson C, Giles FJ, Sabatini DM, Andreeff M, Konopleva M. Zeng Z, et al. Blood. 2007 Apr 15;109(8):3509-12. doi: 10.1182/blood-2006-06-030833. Epub 2006 Dec 19. Blood. 2007. PMID: 17179228 Free PMC article.

7

FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse.

Hentges KE, Sirry B, Gingeras AC, Sarbassov D, Sonenberg N, Sabatini D, Peterson AS. Hentges KE, et al. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13796-801. doi: 10.1073/pnas.241184198. Epub 2001 Nov 13. Proc Natl Acad Sci U S A. 2001. PMID: 11707573 Free PMC article.

8

FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway.

Lin A, Piao HL, Zhuang L, Sarbassov dos D, Ma L, Gan B. Lin A, et al. Cancer Res. 2014 Mar 15;74(6):1682-93. doi: 10.1158/0008-5472.CAN-13-1729. Epub 2014 Jan 21. Cancer Res. 2014. PMID: 24448243 Free PMC article.

9

ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor.

Chen CH, Shaikenov T, Peterson TR, Aimbetov R, Bissenbaev AK, Lee SW, Wu J, Lin HK, Sarbassov dos D. Chen CH, et al. Sci Signal. 2011 Feb 22;4(161):ra10. doi: 10.1126/scisignal.2001731. Sci Signal. 2011. PMID: 21343617

10

The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2.

Chen CH, Sarbassov dos D. Chen CH, et al. J Biol Chem. 2011 Nov 18;286(46):40386-94. doi: 10.1074/jbc.M111.282590. Epub 2011 Sep 30. J Biol Chem. 2011. PMID: 21965657 Free PMC article.

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