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Cocaine blocks HERG, but not KvLQT1+minK, potassium channels.
Zhang S, Rajamani S, Chen Y, Gong Q, Rong Y, Zhou Z, Ruoho A, January CT. Zhang S, et al. Among authors: january ct. Mol Pharmacol. 2001 May;59(5):1069-76. doi: 10.1124/mol.59.5.1069. Mol Pharmacol. 2001. PMID: 11306689
Specific serine proteases selectively damage KCNH2 (hERG1) potassium channels and I(Kr).
Rajamani S, Anderson CL, Valdivia CR, Eckhardt LL, Foell JD, Robertson GA, Kamp TJ, Makielski JC, Anson BD, January CT. Rajamani S, et al. Among authors: january ct. Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1278-88. doi: 10.1152/ajpheart.00777.2005. Epub 2005 Oct 14. Am J Physiol Heart Circ Physiol. 2006. PMID: 16227340 Free article.
Is ranolazine an antiarrhythmic drug?
Eckhardt LL, Teelin TC, January CT. Eckhardt LL, et al. Among authors: january ct. Am J Physiol Heart Circ Physiol. 2008 May;294(5):H1989-91. doi: 10.1152/ajpheart.00285.2008. Epub 2008 Mar 28. Am J Physiol Heart Circ Physiol. 2008. PMID: 18375723 Free article. No abstract available.
133 results