Pojasek K - Search Results

1

Chondroitinase ABC I from Proteus vulgaris: cloning, recombinant expression and active site identification.

Prabhakar V, Capila I, Bosques CJ, Pojasek K, Sasisekharan R. Prabhakar V, et al. Among authors: pojasek k. Biochem J. 2005 Feb 15;386(Pt 1):103-12. doi: 10.1042/BJ20041222. Biochem J. 2005. PMID: 15691229 Free PMC article.

2

Biochemical characterization of the chondroitinase B active site.

Pojasek K, Raman R, Kiley P, Venkataraman G, Sasisekharan R. Pojasek K, et al. J Biol Chem. 2002 Aug 23;277(34):31179-86. doi: 10.1074/jbc.M201552200. Epub 2002 Jun 12. J Biol Chem. 2002. PMID: 12063249 Free article.

3

Biochemical characterization of the chondroitinase ABC I active site.

Prabhakar V, Raman R, Capila I, Bosques CJ, Pojasek K, Sasisekharan R. Prabhakar V, et al. Among authors: pojasek k. Biochem J. 2005 Sep 1;390(Pt 2):395-405. doi: 10.1042/BJ20050532. Biochem J. 2005. PMID: 16108757 Free PMC article.

4

The catalytic machinery of chondroitinase ABC I utilizes a calcium coordination strategy to optimally process dermatan sulfate.

Prabhakar V, Capila I, Raman R, Srinivasan A, Bosques CJ, Pojasek K, Wrick MA, Sasisekharan R. Prabhakar V, et al. Among authors: pojasek k. Biochemistry. 2006 Sep 19;45(37):11130-9. doi: 10.1021/bi0605484. Biochemistry. 2006. PMID: 16964974

5

Recombinant expression, purification, and kinetic characterization of chondroitinase AC and chondroitinase B from Flavobacterium heparinum.

Pojasek K, Shriver Z, Kiley P, Venkataraman G, Sasisekharan R. Pojasek K, et al. Biochem Biophys Res Commun. 2001 Aug 17;286(2):343-51. doi: 10.1006/bbrc.2001.5380. Biochem Biophys Res Commun. 2001. PMID: 11500043

6

The heparin/heparan sulfate 2-O-sulfatase from Flavobacterium heparinum. A structural and biochemical study of the enzyme active site and saccharide substrate specificity.

Raman R, Myette JR, Shriver Z, Pojasek K, Venkataraman G, Sasisekharan R. Raman R, et al. Among authors: pojasek k. J Biol Chem. 2003 Apr 4;278(14):12167-74. doi: 10.1074/jbc.M211425200. Epub 2003 Jan 7. J Biol Chem. 2003. PMID: 12519774 Free article.

7

Heparinase II from Flavobacterium heparinum. Role of cysteine in enzymatic activity as probed by chemical modification and site- directed mutagenesis.

Shriver Z, Hu Y, Pojasek K, Sasisekharan R. Shriver Z, et al. Among authors: pojasek k. J Biol Chem. 1998 Sep 4;273(36):22904-12. doi: 10.1074/jbc.273.36.22904. J Biol Chem. 1998. PMID: 9722510 Free article.

8

Histidine 295 and histidine 510 are crucial for the enzymatic degradation of heparan sulfate by heparinase III.

Pojasek K, Shriver Z, Hu Y, Sasisekharan R. Pojasek K, et al. Biochemistry. 2000 Apr 11;39(14):4012-9. doi: 10.1021/bi992514k. Biochemistry. 2000. PMID: 10747789

9

The structure of chondroitin B lyase complexed with glycosaminoglycan oligosaccharides unravels a calcium-dependent catalytic machinery.

Michel G, Pojasek K, Li Y, Sulea T, Linhardt RJ, Raman R, Prabhakar V, Sasisekharan R, Cygler M. Michel G, et al. Among authors: pojasek k. J Biol Chem. 2004 Jul 30;279(31):32882-96. doi: 10.1074/jbc.M403421200. Epub 2004 May 21. J Biol Chem. 2004. PMID: 15155751 Free PMC article.

10

Modulation of gamma-secretase for the treatment of Alzheimer's disease.

Tate B, McKee TD, Loureiro RM, Dumin JA, Xia W, Pojasek K, Austin WF, Fuller NO, Hubbs JL, Shen R, Jonker J, Ives J, Bronk BS. Tate B, et al. Among authors: pojasek k. Int J Alzheimers Dis. 2012;2012:210756. doi: 10.1155/2012/210756. Epub 2012 Dec 19. Int J Alzheimers Dis. 2012. PMID: 23320246 Free PMC article.

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