Francis SH - Search Results

1

Structural and functional features in human PDE5A1 regulatory domain that provide for allosteric cGMP binding, dimerization, and regulation.

Zoraghi R, Bessay EP, Corbin JD, Francis SH. Zoraghi R, et al. Among authors: francis sh. J Biol Chem. 2005 Mar 25;280(12):12051-63. doi: 10.1074/jbc.M413611200. Epub 2005 Jan 27. J Biol Chem. 2005. PMID: 15677448 Free article.

2

A conserved serine juxtaposed to the pseudosubstrate site of type I cGMP-dependent protein kinase contributes strongly to autoinhibition and lower cGMP affinity.

Busch JL, Bessay EP, Francis SH, Corbin JD. Busch JL, et al. Among authors: francis sh. J Biol Chem. 2002 Sep 13;277(37):34048-54. doi: 10.1074/jbc.M202761200. Epub 2002 Jun 21. J Biol Chem. 2002. PMID: 12080049 Free article.

3

Phosphorylation of isolated human phosphodiesterase-5 regulatory domain induces an apparent conformational change and increases cGMP binding affinity.

Francis SH, Bessay EP, Kotera J, Grimes KA, Liu L, Thompson WJ, Corbin JD. Francis SH, et al. J Biol Chem. 2002 Dec 6;277(49):47581-7. doi: 10.1074/jbc.M206088200. Epub 2002 Sep 30. J Biol Chem. 2002. PMID: 12359732 Free article.

4

cGMP-dependent protein kinase protects cGMP from hydrolysis by phosphodiesterase-5.

Kotera J, Grimes KA, Corbin JD, Francis SH. Kotera J, et al. Among authors: francis sh. Biochem J. 2003 Jun 1;372(Pt 2):419-26. doi: 10.1042/BJ20030107. Biochem J. 2003. PMID: 12617722 Free PMC article.

5

Dimerization of cGMP-dependent protein kinase Ibeta is mediated by an extensive amino-terminal leucine zipper motif, and dimerization modulates enzyme function.

Richie-Jannetta R, Francis SH, Corbin JD. Richie-Jannetta R, et al. Among authors: francis sh. J Biol Chem. 2003 Dec 12;278(50):50070-9. doi: 10.1074/jbc.M306796200. Epub 2003 Aug 21. J Biol Chem. 2003. PMID: 12933804 Free article.

6

Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity.

Huai Q, Liu Y, Francis SH, Corbin JD, Ke H. Huai Q, et al. Among authors: francis sh. J Biol Chem. 2004 Mar 26;279(13):13095-101. doi: 10.1074/jbc.M311556200. Epub 2003 Dec 10. J Biol Chem. 2004. PMID: 14668322 Free article.

7

Properties and functions of GAF domains in cyclic nucleotide phosphodiesterases and other proteins.

Zoraghi R, Corbin JD, Francis SH. Zoraghi R, et al. Among authors: francis sh. Mol Pharmacol. 2004 Feb;65(2):267-78. doi: 10.1124/mol.65.2.267. Mol Pharmacol. 2004. PMID: 14742667 Review. No abstract available.

8

Allosteric sites of phosphodiesterase-5 sequester cyclic GMP.

Kotera J, Francis SH, Grimes KA, Rouse A, Blount MA, Corbin JD. Kotera J, et al. Among authors: francis sh. Front Biosci. 2004 Jan 1;9:378-86. doi: 10.2741/1231. Front Biosci. 2004. PMID: 14766375

9

Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation.

Blount MA, Beasley A, Zoraghi R, Sekhar KR, Bessay EP, Francis SH, Corbin JD. Blount MA, et al. Among authors: francis sh. Mol Pharmacol. 2004 Jul;66(1):144-52. doi: 10.1124/mol.66.1.144. Mol Pharmacol. 2004. PMID: 15213306

10

Molecular properties of mammalian proteins that interact with cGMP: protein kinases, cation channels, phosphodiesterases, and multi-drug anion transporters.

Francis SH, Blount MA, Zoraghi R, Corbin JD. Francis SH, et al. Front Biosci. 2005 Sep 1;10:2097-117. doi: 10.2741/1684. Front Biosci. 2005. PMID: 15970481 Review.

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