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Page 1
SIRT1 shows no substrate specificity in vitro.
Blander G, Olejnik J, Krzymanska-Olejnik E, McDonagh T, Haigis M, Yaffe MB, Guarente L. Blander G, et al. Among authors: mcdonagh t. J Biol Chem. 2005 Mar 18;280(11):9780-5. doi: 10.1074/jbc.M414080200. Epub 2005 Jan 6. J Biol Chem. 2005. PMID: 15640142 Free article.
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells.
Bordone L, Motta MC, Picard F, Robinson A, Jhala US, Apfeld J, McDonagh T, Lemieux M, McBurney M, Szilvasi A, Easlon EJ, Lin SJ, Guarente L. Bordone L, et al. Among authors: mcdonagh t. PLoS Biol. 2006 Feb;4(2):e31. doi: 10.1371/journal.pbio.0040031. Epub 2005 Dec 27. PLoS Biol. 2006. PMID: 16366736 Free PMC article.
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.
Napper AD, Hixon J, McDonagh T, Keavey K, Pons JF, Barker J, Yau WT, Amouzegh P, Flegg A, Hamelin E, Thomas RJ, Kates M, Jones S, Navia MA, Saunders JO, DiStefano PS, Curtis R. Napper AD, et al. Among authors: mcdonagh t. J Med Chem. 2005 Dec 15;48(25):8045-54. doi: 10.1021/jm050522v. J Med Chem. 2005. PMID: 16335928
Substrate-specific activation of sirtuins by resveratrol.
Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK. Kaeberlein M, et al. Among authors: mcdonagh t. J Biol Chem. 2005 Apr 29;280(17):17038-45. doi: 10.1074/jbc.M500655200. Epub 2005 Jan 31. J Biol Chem. 2005. PMID: 15684413 Free article.
Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells.
Bordone L, Motta MC, Picard F, Robinson A, Jhala US, Apfeld J, McDonagh T, Lemieux M, McBurney M, Szilvasi A, Easlon EJ, Lin SJ, Guarente L. Bordone L, et al. Among authors: mcdonagh t. PLoS Biol. 2015 Dec 29;13(12):e1002346. doi: 10.1371/journal.pbio.1002346. eCollection 2015 Dec. PLoS Biol. 2015. PMID: 26714029 Free PMC article. No abstract available.
400 results