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Eleven novel single nucleotide polymorphisms in the NR1I2 (PXR) gene, four of which induce non-synonymous amino acid alterations.
Koyano S, Kurose K, Ozawa S, Saeki M, Nakajima Y, Hasegawa R, Komamura K, Ueno K, Kamakura S, Nakajima T, Saito H, Kimura H, Goto Y, Saitoh O, Katoh M, Ohnuma T, Kawai M, Sugai K, Ohtsuki T, Suzuki C, Minami N, Saito Y, Sawada J. Koyano S, et al. Among authors: nakajima t, nakajima y. Drug Metab Pharmacokinet. 2002;17(6):561-5. doi: 10.2133/dmpk.17.561. Drug Metab Pharmacokinet. 2002. PMID: 15618712 Free article.
Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region.
Koyano S, Kurose K, Saito Y, Ozawa S, Hasegawa R, Komamura K, Ueno K, Kamakura S, Kitakaze M, Nakajima T, Matsumoto K, Akasawa A, Saito H, Sawada J. Koyano S, et al. Among authors: nakajima t. Drug Metab Dispos. 2004 Jan;32(1):149-54. doi: 10.1124/dmd.32.1.149. Drug Metab Dispos. 2004. PMID: 14709632
Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population.
Ikeda S, Kurose K, Ozawa S, Sai K, Hasegawa R, Komamura K, Ueno K, Kamakura S, Kitakaze M, Tomoike H, Nakajima T, Matsumoto K, Saito H, Goto Y, Kimura H, Katoh M, Sugai K, Minami N, Shirao K, Tamura T, Yamamoto N, Minami H, Ohtsu A, Yoshida T, Saijo N, Saito Y, Sawada J. Ikeda S, et al. Among authors: nakajima t. Drug Metab Pharmacokinet. 2003;18(6):413-8. doi: 10.2133/dmpk.18.413. Drug Metab Pharmacokinet. 2003. PMID: 15618763 Free article. No abstract available.
Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population.
Fukushima-Uesaka H, Saito Y, Watanabe H, Shiseki K, Saeki M, Nakamura T, Kurose K, Sai K, Komamura K, Ueno K, Kamakura S, Kitakaze M, Hanai S, Nakajima T, Matsumoto K, Saito H, Goto Y, Kimura H, Katoh M, Sugai K, Minami N, Shirao K, Tamura T, Yamamoto N, Minami H, Ohtsu A, Yoshida T, Saijo N, Kitamura Y, Kamatani N, Ozawa S, Sawada J. Fukushima-Uesaka H, et al. Among authors: nakajima t. Hum Mutat. 2004 Jan;23(1):100. doi: 10.1002/humu.9210. Hum Mutat. 2004. PMID: 14695543
Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (HCE-2).
Kubo T, Kim SR, Sai K, Saito Y, Nakajima T, Matsumoto K, Saito H, Shirao K, Yamamoto N, Minami H, Ohtsu A, Yoshida T, Saijo N, Ohno Y, Ozawa S, Sawada J. Kubo T, et al. Among authors: nakajima t. Drug Metab Dispos. 2005 Oct;33(10):1482-7. doi: 10.1124/dmd.105.005587. Epub 2005 Jul 20. Drug Metab Dispos. 2005. PMID: 16033949
6,016 results