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Interferon-gamma protects against chronic viral myocarditis by reducing mast cell degranulation, fibrosis, and the profibrotic cytokines transforming growth factor-beta 1, interleukin-1 beta, and interleukin-4 in the heart.
Fairweather D, Frisancho-Kiss S, Yusung SA, Barrett MA, Davis SE, Gatewood SJ, Njoku DB, Rose NR. Fairweather D, et al. Among authors: rose nr. Am J Pathol. 2004 Dec;165(6):1883-94. doi: 10.1016/s0002-9440(10)63241-5. Am J Pathol. 2004. PMID: 15579433 Free PMC article.
Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced myocarditis, dilated cardiomyopathy, and heart failure by increasing macrophages, IL-1beta, and immune complex deposition in the heart.
Fairweather D, Frisancho-Kiss S, Njoku DB, Nyland JF, Kaya Z, Yusung SA, Davis SE, Frisancho JA, Barrett MA, Rose NR. Fairweather D, et al. Among authors: rose nr. J Immunol. 2006 Mar 15;176(6):3516-24. doi: 10.4049/jimmunol.176.6.3516. J Immunol. 2006. PMID: 16517720
590 results