Boot-Handford RP - Search Results

1

Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway.

Wang X, Merritt AJ, Seyfried J, Guo C, Papadakis ES, Finegan KG, Kayahara M, Dixon J, Boot-Handford RP, Cartwright EJ, Mayer U, Tournier C. Wang X, et al. Mol Cell Biol. 2005 Jan;25(1):336-45. doi: 10.1128/MCB.25.1.336-345.2005. Mol Cell Biol. 2005. PMID: 15601854 Free PMC article.

2

Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death.

Wang X, Nadarajah B, Robinson AC, McColl BW, Jin JW, Dajas-Bailador F, Boot-Handford RP, Tournier C. Wang X, et al. Mol Cell Biol. 2007 Nov;27(22):7935-46. doi: 10.1128/MCB.00226-07. Epub 2007 Sep 17. Mol Cell Biol. 2007. PMID: 17875933 Free PMC article.

3

Activation of extracellular signal-regulated protein kinase 5 downregulates FasL upon osmotic stress.

Wang X, Finegan KG, Robinson AC, Knowles L, Khosravi-Far R, Hinchliffe KA, Boot-Handford RP, Tournier C. Wang X, et al. Cell Death Differ. 2006 Dec;13(12):2099-108. doi: 10.1038/sj.cdd.4401969. Epub 2006 May 19. Cell Death Differ. 2006. PMID: 16710360

4

Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch.

Richardson RJ, Dixon J, Malhotra S, Hardman MJ, Knowles L, Boot-Handford RP, Shore P, Whitmarsh A, Dixon MJ. Richardson RJ, et al. Nat Genet. 2006 Nov;38(11):1329-34. doi: 10.1038/ng1894. Epub 2006 Oct 15. Nat Genet. 2006. PMID: 17041603

5

Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation.

Leighton MP, Nundlall S, Starborg T, Meadows RS, Suleman F, Knowles L, Wagener R, Thornton DJ, Kadler KE, Boot-Handford RP, Briggs MD. Leighton MP, et al. Hum Mol Genet. 2007 Jul 15;16(14):1728-41. doi: 10.1093/hmg/ddm121. Epub 2007 May 21. Hum Mol Genet. 2007. PMID: 17517694 Free PMC article.

6

A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth.

Gualeni B, Rajpar MH, Kellogg A, Bell PA, Arvan P, Boot-Handford RP, Briggs MD. Gualeni B, et al. Dis Model Mech. 2013 Nov;6(6):1414-25. doi: 10.1242/dmm.013342. Epub 2013 Sep 12. Dis Model Mech. 2013. PMID: 24046357 Free PMC article.

7

An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia.

Nundlall S, Rajpar MH, Bell PA, Clowes C, Zeeff LA, Gardner B, Thornton DJ, Boot-Handford RP, Briggs MD. Nundlall S, et al. Cell Stress Chaperones. 2010 Nov;15(6):835-49. doi: 10.1007/s12192-010-0193-y. Epub 2010 Apr 30. Cell Stress Chaperones. 2010. PMID: 20428984 Free PMC article.

8

An enhancer complex confers both high-level and cell-specific expression of the human type X collagen gene.

Chambers D, Young DA, Howard C, Thomas JT, Boam DS, Grant ME, Wallis GA, Boot-Handford RP. Chambers D, et al. FEBS Lett. 2002 Nov 20;531(3):505-8. doi: 10.1016/s0014-5793(02)03606-2. FEBS Lett. 2002. PMID: 12435601 Free article.

9

Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio).

Mould AP, McLeish JA, Huxley-Jones J, Goonesinghe AC, Hurlstone AF, Boot-Handford RP, Humphries MJ. Mould AP, et al. BMC Cell Biol. 2006 Jun 20;7:24. doi: 10.1186/1471-2121-7-24. BMC Cell Biol. 2006. PMID: 16787535 Free PMC article.

10

Bub1 maintains centromeric cohesion by activation of the spindle checkpoint.

Perera D, Tilston V, Hopwood JA, Barchi M, Boot-Handford RP, Taylor SS. Perera D, et al. Dev Cell. 2007 Oct;13(4):566-79. doi: 10.1016/j.devcel.2007.08.008. Dev Cell. 2007. PMID: 17925231 Free article.

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