Leach MO - Search Results

1

Investigations in vivo of the effects of carbogen breathing on 5-fluorouracil pharmacokinetics and physiology of solid rodent tumours.

McSheehy PM, Port RE, Rodrigues LM, Robinson SP, Stubbs M, van der Borns K, Peters GJ, Judson IR, Leach MO, Griffiths JR. McSheehy PM, et al. Among authors: leach mo. Cancer Chemother Pharmacol. 2005 Feb;55(2):117-28. doi: 10.1007/s00280-004-0851-9. Epub 2004 Oct 5. Cancer Chemother Pharmacol. 2005. PMID: 15592719

2

A pharmacokinetic and pharmacodynamic study in vivo of human HT29 tumours using 19F and 31P magnetic resonance spectroscopy.

McSheehy PM, Seymour MT, Ojugo AS, Rodrigues LM, Leach MO, Judson IR, Griffiths JR. McSheehy PM, et al. Among authors: leach mo. Eur J Cancer. 1997 Dec;33(14):2418-27. doi: 10.1016/s0959-8049(97)00336-5. Eur J Cancer. 1997. PMID: 9616292

3

Measurement of the extracellular pH of solid tumours in mice by magnetic resonance spectroscopy: a comparison of exogenous (19)F and (31)P probes.

Ojugo AS, McSheehy PM, McIntyre DJ, McCoy C, Stubbs M, Leach MO, Judson IR, Griffiths JR. Ojugo AS, et al. Among authors: leach mo. NMR Biomed. 1999 Dec;12(8):495-504. doi: 10.1002/(sici)1099-1492(199912)12:8<495::aid-nbm594>3.0.co;2-k. NMR Biomed. 1999. PMID: 10668042

4

Metabolites of 2'-fluoro-2'-deoxy-D-glucose detected by 19F magnetic resonance spectroscopy in vivo predict response of murine RIF-1 tumors to 5-fluorouracil.

McSheehy PM, Leach MO, Judson IR, Griffiths JR. McSheehy PM, et al. Among authors: leach mo. Cancer Res. 2000 Apr 15;60(8):2122-7. Cancer Res. 2000. PMID: 10786672

5

Increased tumour extracellular pH induced by Bafilomycin A1 inhibits tumour growth and mitosis in vivo and alters 5-fluorouracil pharmacokinetics.

McSheehy PM, Troy H, Kelland LR, Judson IR, Leach MO, Griffiths JR. McSheehy PM, et al. Among authors: leach mo. Eur J Cancer. 2003 Mar;39(4):532-40. doi: 10.1016/s0959-8049(02)00671-8. Eur J Cancer. 2003. PMID: 12751386

6

Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumors: a magnetic resonance study in vivo.

McSheehy PM, Robinson SP, Ojugo AS, Aboagye EO, Cannell MB, Leach MO, Judson IR, Griffiths JR. McSheehy PM, et al. Among authors: leach mo. Cancer Res. 1998 Mar 15;58(6):1185-94. Cancer Res. 1998. PMID: 9515804

7

Influence of pH on the uptake of 5-fluorouracil into isolated tumour cells.

Ojugo AS, McSheehy PM, Stubbs M, Alder G, Bashford CL, Maxwell RJ, Leach MO, Judson IR, Griffiths JR. Ojugo AS, et al. Among authors: leach mo. Br J Cancer. 1998 Mar;77(6):873-9. doi: 10.1038/bjc.1998.144. Br J Cancer. 1998. PMID: 9528827 Free PMC article.

8

In vivo hyperpolarized 129Xe NMR spectroscopy in tumors.

Wolber J, McIntyre DJ, Rodrigues LM, Carnochan P, Griffiths JR, Leach MO, Bifone A. Wolber J, et al. Among authors: leach mo. Magn Reson Med. 2001 Sep;46(3):586-91. doi: 10.1002/mrm.1231. Magn Reson Med. 2001. PMID: 11550253 Free article.

9

Magnetic resonance detects metabolic changes associated with chemotherapy-induced apoptosis.

Ronen SM, DiStefano F, McCoy CL, Robertson D, Smith TA, Al-Saffar NM, Titley J, Cunningham DC, Griffiths JR, Leach MO, Clarke PA. Ronen SM, et al. Among authors: leach mo. Br J Cancer. 1999 Jun;80(7):1035-41. doi: 10.1038/sj.bjc.6690459. Br J Cancer. 1999. PMID: 10362112 Free PMC article.

10

The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations.

Leach MO, Brindle KM, Evelhoch JL, Griffiths JR, Horsman MR, Jackson A, Jayson GC, Judson IR, Knopp MV, Maxwell RJ, McIntyre D, Padhani AR, Price P, Rathbone R, Rustin GJ, Tofts PS, Tozer GM, Vennart W, Waterton JC, Williams SR, Workman P; Pharmacodynamic/Pharmacokinetic Technologies Advisory Committee, Drug Development Office, Cancer Research UK. Leach MO, et al. Br J Cancer. 2005 May 9;92(9):1599-610. doi: 10.1038/sj.bjc.6602550. Br J Cancer. 2005. PMID: 15870830 Free PMC article.

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