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Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications.
Iso Y, Grajkowska E, Wroblewski JT, Davis J, Goeders NE, Johnson KM, Sanker S, Roth BL, Tueckmantel W, Kozikowski AP. Iso Y, et al. Among authors: grajkowska e. J Med Chem. 2006 Feb 9;49(3):1080-100. doi: 10.1021/jm050570f. J Med Chem. 2006. PMID: 16451073
The protective signaling of metabotropic glutamate receptor 1 Is mediated by sustained, beta-arrestin-1-dependent ERK phosphorylation.
Emery AC, Pshenichkin S, Takoudjou GR, Grajkowska E, Wolfe BB, Wroblewski JT. Emery AC, et al. Among authors: grajkowska e. J Biol Chem. 2010 Aug 20;285(34):26041-8. doi: 10.1074/jbc.M110.139899. Epub 2010 Jun 21. J Biol Chem. 2010. PMID: 20566651 Free PMC article.
In this capacity, we have reported previously that in neuronal cells, mGlu1a exhibits the properties of a dependence receptor, inducing apoptosis in the absence of glutamate, while promoting neuronal survival in its presence (Pshenichkin, S., Dolinska, M., Klauzinska, M., Luchenk …
In this capacity, we have reported previously that in neuronal cells, mGlu1a exhibits the properties of a dependence receptor, inducing apop …
Ligand bias at metabotropic glutamate 1a receptors: molecular determinants that distinguish β-arrestin-mediated from G protein-mediated signaling.
Emery AC, DiRaddo JO, Miller E, Hathaway HA, Pshenichkin S, Takoudjou GR, Grajkowska E, Yasuda RP, Wolfe BB, Wroblewski JT. Emery AC, et al. Among authors: grajkowska e. Mol Pharmacol. 2012 Aug;82(2):291-301. doi: 10.1124/mol.112.078444. Epub 2012 May 14. Mol Pharmacol. 2012. PMID: 22584219 Free PMC article.
29 results