Alagille D - Search Results

1

Synthesis and receptor assay of aromatic-ethynyl-aromatic derivatives with potent mGluR5 antagonist activity.

Alagille D, Baldwin RM, Roth BL, Wroblewski JT, Grajkowska E, Tamagnan GD. Alagille D, et al. Bioorg Med Chem. 2005 Jan 3;13(1):197-209. doi: 10.1016/j.bmc.2004.09.042. Bioorg Med Chem. 2005. PMID: 15582465

2

Functionalization at position 3 of the phenyl ring of the potent mGluR5 noncompetitive antagonists MPEP.

Alagille D, Baldwin RM, Roth BL, Wroblewski JT, Grajkowska E, Tamagnan GD. Alagille D, et al. Bioorg Med Chem Lett. 2005 Feb 15;15(4):945-9. doi: 10.1016/j.bmcl.2004.12.047. Bioorg Med Chem Lett. 2005. PMID: 15686891

3

Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[4-(substituted thiophenyl)]phenyltropanes: discovery of a selective SERT antagonist with picomolar potency.

Tamagnan G, Alagille D, Fu X, Kula NS, Baldessarini RJ, Innis RB, Baldwin RM. Tamagnan G, et al. Among authors: alagille d. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1131-3. doi: 10.1016/j.bmcl.2004.12.014. Bioorg Med Chem Lett. 2005. PMID: 15686927

4

Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[aryl or heteroaryl]phenyltropanes.

Tamagnan G, Alagille D, Fu X, Kula NS, Baldessarini RJ, Innis RB, Baldwin RM. Tamagnan G, et al. Among authors: alagille d. Bioorg Med Chem Lett. 2006 Jan 1;16(1):217-20. doi: 10.1016/j.bmcl.2005.09.016. Epub 2005 Oct 19. Bioorg Med Chem Lett. 2006. PMID: 16236497

5

Synthesis of 5- and 6-substituted 2-(4-dimethylaminophenyl)-1,3-benzoxazoles and their in vitro and in vivo evaluation as imaging agents for amyloid plaque.

Hausner SH, Alagille D, Koren AO, Amici L, Staley JK, Cosgrove KP, Baldwin RM, Tamagnan GD. Hausner SH, et al. Among authors: alagille d. Bioorg Med Chem Lett. 2009 Jan 15;19(2):543-5. doi: 10.1016/j.bmcl.2008.05.033. Epub 2008 May 15. Bioorg Med Chem Lett. 2009. PMID: 19081717 Free PMC article.

6

Potent mGluR5 antagonists: pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series.

Alagille D, DaCosta H, Chen Y, Hemstapat K, Rodriguez A, Baldwin RM, Conn PJ, Tamagnan GD. Alagille D, et al. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3243-7. doi: 10.1016/j.bmcl.2011.04.047. Epub 2011 Apr 20. Bioorg Med Chem Lett. 2011. PMID: 21546249 Free PMC article.

7

Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes.

de Paulis T, Hemstapat K, Chen Y, Zhang Y, Saleh S, Alagille D, Baldwin RM, Tamagnan GD, Conn PJ. de Paulis T, et al. Among authors: alagille d. J Med Chem. 2006 Jun 1;49(11):3332-44. doi: 10.1021/jm051252j. J Med Chem. 2006. PMID: 16722652

8

Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER.

Tamagnan GD, Brenner E, Alagille D, Staley JK, Haile C, Koren A, Early M, Baldwin RM, Tarazi FI, Baldessarini RJ, Jarkas N, Goodman MM, Seibyl JP. Tamagnan GD, et al. Among authors: alagille d. Bioorg Med Chem Lett. 2007 Jan 15;17(2):533-7. doi: 10.1016/j.bmcl.2006.10.018. Epub 2006 Oct 12. Bioorg Med Chem Lett. 2007. PMID: 17095215 Free PMC article.

9

2-Arylimidazo[2,1-b]benzothiazoles: a new family of amyloid binding agents with potential for PET and SPECT imaging of Alzheimer's brain.

Alagille D, DaCosta H, Baldwin RM, Tamagnan GD. Alagille D, et al. Bioorg Med Chem Lett. 2011 May 15;21(10):2966-8. doi: 10.1016/j.bmcl.2011.03.052. Epub 2011 Mar 21. Bioorg Med Chem Lett. 2011. PMID: 21458990

10

Synthesis and biological evaluation of positron emission tomography radiotracers targeting serotonin 4 receptors in brain: [18F]MNI-698 and [18F]MNI-699.

Caillé F, Morley TJ, Tavares AA, Papin C, Twardy NM, Alagille D, Lee HS, Baldwin RM, Seibyl JP, Barret O, Tamagnan GD. Caillé F, et al. Among authors: alagille d. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6243-7. doi: 10.1016/j.bmcl.2013.09.097. Epub 2013 Oct 9. Bioorg Med Chem Lett. 2013. PMID: 24157369

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