Geacintov NE - Search Results

1

Structure of a high fidelity DNA polymerase bound to a benzo[a]pyrene adduct that blocks replication.

Hsu GW, Huang X, Luneva NP, Geacintov NE, Beese LS. Hsu GW, et al. Among authors: geacintov ne. J Biol Chem. 2005 Feb 4;280(5):3764-70. doi: 10.1074/jbc.M411276200. Epub 2004 Nov 16. J Biol Chem. 2005. PMID: 15548515 Free article.

2

Following an environmental carcinogen N2-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase.

Xu P, Oum L, Beese LS, Geacintov NE, Broyde S. Xu P, et al. Among authors: geacintov ne. Nucleic Acids Res. 2007;35(13):4275-88. doi: 10.1093/nar/gkm416. Epub 2007 Jun 18. Nucleic Acids Res. 2007. PMID: 17576677 Free PMC article.

3

Solution conformation of the (-)-cis-anti-benzo[a]pyrenyl-dG adduct opposite dC in a DNA duplex: intercalation of the covalently attached BP ring into the helix with base displacement of the modified deoxyguanosine into the major groove.

Cosman M, Hingerty BE, Luneva N, Amin S, Geacintov NE, Broyde S, Patel DJ. Cosman M, et al. Among authors: geacintov ne. Biochemistry. 1996 Jul 30;35(30):9850-63. doi: 10.1021/bi9605346. Biochemistry. 1996. PMID: 8703959

4

Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement.

Zhang N, Lin C, Huang X, Kolbanovskiy A, Hingerty BE, Amin S, Broyde S, Geacintov NE, Patel DJ. Zhang N, et al. Among authors: geacintov ne. J Mol Biol. 2005 Mar 4;346(4):951-65. doi: 10.1016/j.jmb.2004.12.027. Epub 2004 Dec 31. J Mol Biol. 2005. PMID: 15701509 Free PMC article.

5

Conformational changes of a benzo[a]pyrene diol epoxide-N(2)-dG adduct induced by a 5'-flanking 5-methyl-substituted cytosine in a (Me)CG double-stranded oligonucleotide sequence context.

Huang X, Colgate KC, Kolbanovskiy A, Amin S, Geacintov NE. Huang X, et al. Among authors: geacintov ne. Chem Res Toxicol. 2002 Mar;15(3):438-44. doi: 10.1021/tx015588h. Chem Res Toxicol. 2002. PMID: 11896693

6

Base pair conformation-dependent excision of benzo[a]pyrene diol epoxide-guanine adducts by human nucleotide excision repair enzymes.

Hess MT, Gunz D, Luneva N, Geacintov NE, Naegeli H. Hess MT, et al. Among authors: geacintov ne. Mol Cell Biol. 1997 Dec;17(12):7069-76. doi: 10.1128/MCB.17.12.7069. Mol Cell Biol. 1997. PMID: 9372938 Free PMC article.

7

Quantitative analysis of translesion DNA synthesis across a benzo[a]pyrene-guanine adduct in mammalian cells: the role of DNA polymerase kappa.

Avkin S, Goldsmith M, Velasco-Miguel S, Geacintov N, Friedberg EC, Livneh Z. Avkin S, et al. J Biol Chem. 2004 Dec 17;279(51):53298-305. doi: 10.1074/jbc.M409155200. Epub 2004 Oct 9. J Biol Chem. 2004. PMID: 15475561 Free article.

8

Unrepaired fjord region polycyclic aromatic hydrocarbon-DNA adducts in ras codon 61 mutational hot spots.

Buterin T, Hess MT, Luneva N, Geacintov NE, Amin S, Kroth H, Seidel A, Naegeli H. Buterin T, et al. Among authors: geacintov ne. Cancer Res. 2000 Apr 1;60(7):1849-56. Cancer Res. 2000. PMID: 10766171

9

Molecular topology of polycyclic aromatic carcinogens determines DNA adduct conformation: a link to tumorigenic activity.

Lin CH, Huang X, Kolbanovskii A, Hingerty BE, Amin S, Broyde S, Geacintov NE, Patel DJ. Lin CH, et al. Among authors: geacintov ne. J Mol Biol. 2001 Mar 9;306(5):1059-80. doi: 10.1006/jmbi.2001.4425. J Mol Biol. 2001. PMID: 11237618

10

trans-Lesion synthesis past bulky benzo[a]pyrene diol epoxide N2-dG and N6-dA lesions catalyzed by DNA bypass polymerases.

Rechkoblit O, Zhang Y, Guo D, Wang Z, Amin S, Krzeminsky J, Louneva N, Geacintov NE. Rechkoblit O, et al. Among authors: geacintov ne. J Biol Chem. 2002 Aug 23;277(34):30488-94. doi: 10.1074/jbc.M201167200. Epub 2002 Jun 12. J Biol Chem. 2002. PMID: 12063247 Free article.

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