Matter H - Search Results

1

Custom chemical microarray production and affinity fingerprinting for the S1 pocket of factor VIIa.

Dickopf S, Frank M, Junker HD, Maier S, Metz G, Ottleben H, Rau H, Schellhaas N, Schmidt K, Sekul R, Vanier C, Vetter D, Czech J, Lorenz M, Matter H, Schudok M, Schreuder H, Will DW, Nestler HP. Dickopf S, et al. Among authors: matter h. Anal Biochem. 2004 Dec 1;335(1):50-7. doi: 10.1016/j.ab.2004.08.033. Anal Biochem. 2004. PMID: 15519570

2

Design, synthesis, and structure-activity relationship of a new class of amidinophenylurea-based factor VIIa inhibitors.

Klingler O, Matter H, Schudok M, Bajaj SP, Czech J, Lorenz M, Nestler HP, Schreuder H, Wildgoose P. Klingler O, et al. Among authors: matter h. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1463-7. doi: 10.1016/s0960-894x(03)00168-9. Bioorg Med Chem Lett. 2003. PMID: 12668013

3

Structure-based design of amidinophenylurea-derivatives for factor VIIa inhibition.

Klingler O, Matter H, Schudok M, Donghi M, Czech J, Lorenz M, Nestler HP, Szillat H, Schreuder H. Klingler O, et al. Among authors: matter h. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3715-20. doi: 10.1016/j.bmcl.2004.05.006. Bioorg Med Chem Lett. 2004. PMID: 15203149

4

Novel factor Xa inhibitors based on a benzoic acid scaffold and incorporating a neutral P1 ligand.

Nazaré M, Matter H, Klingler O, Al-Obeidi F, Schreuder H, Zoller G, Czech J, Lorenz M, Dudda A, Peyman A, Nestler HP, Urmann M, Bauer A, Laux V, Wehner V, Will DW. Nazaré M, et al. Among authors: matter h. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2801-5. doi: 10.1016/j.bmcl.2004.03.059. Bioorg Med Chem Lett. 2004. PMID: 15125936

5

Structural requirements for factor Xa inhibition by 3-oxybenzamides with neutral P1 substituents: combining X-ray crystallography, 3D-QSAR, and tailored scoring functions.

Matter H, Will DW, Nazaré M, Schreuder H, Laux V, Wehner V. Matter H, et al. J Med Chem. 2005 May 5;48(9):3290-312. doi: 10.1021/jm049187l. J Med Chem. 2005. PMID: 15857135

6

Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents.

Nazaré M, Essrich M, Will DW, Matter H, Ritter K, Urmann M, Bauer A, Schreuder H, Dudda A, Czech J, Lorenz M, Laux V, Wehner V. Nazaré M, et al. Among authors: matter h. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4191-5. doi: 10.1016/j.bmcl.2004.06.020. Bioorg Med Chem Lett. 2004. PMID: 15261268

7

Novel factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of P4 substituents in combination with a neutral P1 ligand.

Nazaré M, Essrich M, Will DW, Matter H, Ritter K, Urmann M, Bauer A, Schreuder H, Czech J, Lorenz M, Laux V, Wehner V. Nazaré M, et al. Among authors: matter h. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4197-201. doi: 10.1016/j.bmcl.2004.06.019. Bioorg Med Chem Lett. 2004. PMID: 15261269

8

Recent advances in the design of matrix metalloprotease inhibitors.

Matter H, Schudok M. Matter H, et al. Curr Opin Drug Discov Devel. 2004 Jul;7(4):513-35. Curr Opin Drug Discov Devel. 2004. PMID: 15338961 Review.

9

Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: a study combining structure-activity relationship and X-ray crystallography.

Nazaré M, Will DW, Matter H, Schreuder H, Ritter K, Urmann M, Essrich M, Bauer A, Wagner M, Czech J, Lorenz M, Laux V, Wehner V. Nazaré M, et al. Among authors: matter h. J Med Chem. 2005 Jul 14;48(14):4511-25. doi: 10.1021/jm0490540. J Med Chem. 2005. PMID: 15999990

10

QSAR-by-NMR: quantitative insights into structural determinants for binding affinity by analysis of 1H/15N chemical shift differences in MMP-3 ligands.

Matter H, Schudok M, Elshorst B, Jacobs DM, Saxena K, Kogler H. Matter H, et al. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1779-83. doi: 10.1016/j.bmcl.2005.02.048. Bioorg Med Chem Lett. 2005. PMID: 15780605

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