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Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation.
Kurita A, Miyauchi Y, Ikushiro S, Mackenzie PI, Yamada H, Ishii Y. Kurita A, et al. Among authors: mackenzie pi. J Pharmacol Exp Ther. 2017 May;361(2):199-208. doi: 10.1124/jpet.117.240382. Epub 2017 Feb 22. J Pharmacol Exp Ther. 2017. PMID: 28228532 Free article.
Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants.
Ishii Y, Koba H, Kinoshita K, Oizaki T, Iwamoto Y, Takeda S, Miyauchi Y, Nishimura Y, Egoshi N, Taura F, Morimoto S, Ikushiro S, Nagata K, Yamazoe Y, Mackenzie PI, Yamada H. Ishii Y, et al. Among authors: mackenzie pi. Drug Metab Dispos. 2014 Feb;42(2):229-38. doi: 10.1124/dmd.113.054833. Epub 2013 Nov 19. Drug Metab Dispos. 2014. PMID: 24255116
Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.
Miyauchi Y, Kurita A, Yamashita R, Takamatsu T, Ikushiro S, Mackenzie PI, Tanaka Y, Ishii Y. Miyauchi Y, et al. Among authors: mackenzie pi. Biochem Biophys Res Commun. 2020 Apr 30;525(2):348-353. doi: 10.1016/j.bbrc.2020.02.075. Epub 2020 Feb 21. Biochem Biophys Res Commun. 2020. PMID: 32093886
188 results