Pradeepkumar PI - Search Results

1

Oxetane modified, conformationally constrained, antisense oligodeoxyribonucleotides function efficiently as gene silencing molecules.

Opalinska JB, Kalota A, Gifford LK, Lu P, Jen KY, Pradeepkumar PI, Barman J, Kim TK, Swider CR, Chattopadhyaya J, Gewirtz AM. Opalinska JB, et al. Among authors: pradeepkumar pi. Nucleic Acids Res. 2004 Oct 28;32(19):5791-9. doi: 10.1093/nar/gkh893. Print 2004. Nucleic Acids Res. 2004. PMID: 15514112 Free PMC article.

2

Antisense oligonuclotides with oxetane-constrained cytidine enhance heteroduplex stability, and elicit satisfactory RNase H response as well as showing improved resistance to both exo and endonucleases.

Pradeepkumar PI, Amirkhanov NV, Chattopadhyaya J. Pradeepkumar PI, et al. Org Biomol Chem. 2003 Jan 7;1(1):81-92. doi: 10.1039/b210163g. Org Biomol Chem. 2003. PMID: 12929393

3

A critical survey of the structure-function of the antisense oligo/RNA heteroduplex as substrate for RNase H.

Zamaratski E, Pradeepkumar PI, Chattopadhyaya J. Zamaratski E, et al. Among authors: pradeepkumar pi. J Biochem Biophys Methods. 2001 May 28;48(3):189-208. doi: 10.1016/s0165-022x(01)00149-x. J Biochem Biophys Methods. 2001. PMID: 11384757 Review.

4

Oxetane locked thymidine in the Dickerson-Drew dodecamer causes local base pairing distortions -- an NMR structure and hydration study.

Isaksson J, Plashkevych O, Pradeepkumar PI, Chatterjee S, Barman J, Pathmasiri W, Shrivastava P, Petit C, Chattopadhyaya J. Isaksson J, et al. Among authors: pradeepkumar pi. J Biomol Struct Dyn. 2005 Dec;23(3):299-330. doi: 10.1080/07391102.2005.10507067. J Biomol Struct Dyn. 2005. PMID: 16218756

5

Synthesis, physicochemical and biochemical studies of 1',2'-oxetane constrained adenosine and guanosine modified oligonucleotides, and their comparison with those of the corresponding cytidine and thymidine analogues.

Pradeepkumar PI, Cheruku P, Plashkevych O, Acharya P, Gohil S, Chattopadhyaya J. Pradeepkumar PI, et al. J Am Chem Soc. 2004 Sep 22;126(37):11484-99. doi: 10.1021/ja048417i. J Am Chem Soc. 2004. PMID: 15366894

6

Synthesis of [Ru(phen)(2)dppz](2+)-tethered oligo-DNA and studies on the metallointercalation mode into the DNA duplex.

Ossipov D, Pradeepkumar PI, Holmer M, Chattopadhyaya J. Ossipov D, et al. Among authors: pradeepkumar pi. J Am Chem Soc. 2001 Apr 18;123(15):3551-62. doi: 10.1021/ja003985t. J Am Chem Soc. 2001. PMID: 11472126

7

An electrochemical probe of DNA stacking in an antisense oligonucleotide containing a C3'-endo-locked sugar.

Boon EM, Barton JK, Pradeepkumar PI, Isaksson J, Petit C, Chattopadhyaya J. Boon EM, et al. Among authors: pradeepkumar pi. Angew Chem Int Ed Engl. 2002 Sep 16;41(18):3402-5. doi: 10.1002/1521-3773(20020916)41:18<3402::AID-ANIE3402>3.0.CO;2-6. Angew Chem Int Ed Engl. 2002. PMID: 12298045 No abstract available.

8

Effect of 2'-5'/3'-5' phosphodiester linkage heterogeneity on RNA interference.

Habibian M, Harikrishna S, Fakhoury J, Barton M, Ageely EA, Cencic R, Fakih HH, Katolik A, Takahashi M, Rossi J, Pelletier J, Gagnon KT, Pradeepkumar PI, Damha MJ. Habibian M, et al. Among authors: pradeepkumar pi. Nucleic Acids Res. 2020 May 21;48(9):4643-4657. doi: 10.1093/nar/gkaa222. Nucleic Acids Res. 2020. PMID: 32282904 Free PMC article.

9

Synthesis, gene silencing, and molecular modeling studies of 4'-C-aminomethyl-2'-O-methyl modified small interfering RNAs.

Gore KR, Nawale GN, Harikrishna S, Chittoor VG, Pandey SK, Höbartner C, Patankar S, Pradeepkumar PI. Gore KR, et al. Among authors: pradeepkumar pi. J Org Chem. 2012 Apr 6;77(7):3233-45. doi: 10.1021/jo202666m. Epub 2012 Mar 16. J Org Chem. 2012. PMID: 22372696

10

Nucleoside Analogues with a Seven-Membered Sugar Ring: Synthesis and Structural Compatibility in DNA-RNA Hybrids.

Jana SK, Harikrishna S, Sudhakar S, El-Khoury R, Pradeepkumar PI, Damha MJ. Jana SK, et al. Among authors: pradeepkumar pi. J Org Chem. 2022 Mar 4;87(5):2367-2379. doi: 10.1021/acs.joc.1c02254. Epub 2022 Feb 8. J Org Chem. 2022. PMID: 35133166

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