Neidle S - Search Results

1

Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding.

Harrison RJ, Reszka AP, Haider SM, Romagnoli B, Morrell J, Read MA, Gowan SM, Incles CM, Kelland LR, Neidle S. Harrison RJ, et al. Among authors: neidle s. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5845-9. doi: 10.1016/j.bmcl.2004.09.037. Bioorg Med Chem Lett. 2004. PMID: 15501053

2

A molecular modeling study of the interactions between the antiestrogen drug tamoxifen and several derivatives, and the calcium-binding protein calmodulin.

Edwards KJ, Laughton CA, Neidle S. Edwards KJ, et al. Among authors: neidle s. J Med Chem. 1992 Jul 24;35(15):2753-61. doi: 10.1021/jm00093a006. J Med Chem. 1992. PMID: 1322985

3

Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives.

Agbandje M, Jenkins TC, McKenna R, Reszka AP, Neidle S. Agbandje M, et al. Among authors: neidle s. J Med Chem. 1992 Apr 17;35(8):1418-29. doi: 10.1021/jm00086a010. J Med Chem. 1992. PMID: 1573635

4

Inhibitors of the P450 enzymes aromatase and lyase. Crystallographic and molecular modeling studies suggest structural features of pyridylacetic acid derivatives responsible for differences in enzyme inhibitory activity.

Laughton CA, Neidle S. Laughton CA, et al. Among authors: neidle s. J Med Chem. 1990 Nov;33(11):3055-60. doi: 10.1021/jm00173a023. J Med Chem. 1990. PMID: 2231605

5

Synthesis, molecular modeling, DNA binding, and antitumor properties of some substituted amidoanthraquinones.

Collier DA, Neidle S. Collier DA, et al. Among authors: neidle s. J Med Chem. 1988 Apr;31(4):847-57. doi: 10.1021/jm00399a028. J Med Chem. 1988. PMID: 3351863

6

Characteristics of triplex-directed photoadduct formation by psoralen-linked oligodeoxynucleotides.

Bates PJ, Macaulay VM, McLean MJ, Jenkins TC, Reszka AP, Laughton CA, Neidle S. Bates PJ, et al. Among authors: neidle s. Nucleic Acids Res. 1995 Nov 11;23(21):4283-9. doi: 10.1093/nar/23.21.4283. Nucleic Acids Res. 1995. PMID: 7501447 Free PMC article.

7

Perturbations in DNA structure upon interaction with porphyrins revealed by chemical probes, DNA footprinting and molecular modelling.

Ford KG, Neidle S. Ford KG, et al. Among authors: neidle s. Bioorg Med Chem. 1995 Jun;3(6):671-7. doi: 10.1016/0968-0896(95)00052-i. Bioorg Med Chem. 1995. PMID: 7582945

8

Targeting the minor groove of DNA: crystal structures of two complexes between furan derivatives of berenil and the DNA dodecamer d(CGCGAATTCGCG)2.

Trent JO, Clark GR, Kumar A, Wilson WD, Boykin DW, Hall JE, Tidwell RR, Blagburn BL, Neidle S. Trent JO, et al. Among authors: neidle s. J Med Chem. 1996 Nov 8;39(23):4554-62. doi: 10.1021/jm9604484. J Med Chem. 1996. PMID: 8917643

9

1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase.

Perry PJ, Gowan SM, Reszka AP, Polucci P, Jenkins TC, Kelland LR, Neidle S. Perry PJ, et al. Among authors: neidle s. J Med Chem. 1998 Aug 13;41(17):3253-60. doi: 10.1021/jm9801105. J Med Chem. 1998. PMID: 9703471

10

Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones.

Perry PJ, Reszka AP, Wood AA, Read MA, Gowan SM, Dosanjh HS, Trent JO, Jenkins TC, Kelland LR, Neidle S. Perry PJ, et al. Among authors: neidle s. J Med Chem. 1998 Nov 19;41(24):4873-84. doi: 10.1021/jm981067o. J Med Chem. 1998. PMID: 9822556

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