Gowan SM - Search Results

1

Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding.

Harrison RJ, Reszka AP, Haider SM, Romagnoli B, Morrell J, Read MA, Gowan SM, Incles CM, Kelland LR, Neidle S. Harrison RJ, et al. Among authors: gowan sm. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5845-9. doi: 10.1016/j.bmcl.2004.09.037. Bioorg Med Chem Lett. 2004. PMID: 15501053

2

1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase.

Perry PJ, Gowan SM, Reszka AP, Polucci P, Jenkins TC, Kelland LR, Neidle S. Perry PJ, et al. Among authors: gowan sm. J Med Chem. 1998 Aug 13;41(17):3253-60. doi: 10.1021/jm9801105. J Med Chem. 1998. PMID: 9703471

3

Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones.

Perry PJ, Reszka AP, Wood AA, Read MA, Gowan SM, Dosanjh HS, Trent JO, Jenkins TC, Kelland LR, Neidle S. Perry PJ, et al. Among authors: gowan sm. J Med Chem. 1998 Nov 19;41(24):4873-84. doi: 10.1021/jm981067o. J Med Chem. 1998. PMID: 9822556

4

2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase.

Perry PJ, Read MA, Davies RT, Gowan SM, Reszka AP, Wood AA, Kelland LR, Neidle S. Perry PJ, et al. Among authors: gowan sm. J Med Chem. 1999 Jul 15;42(14):2679-84. doi: 10.1021/jm990084q. J Med Chem. 1999. PMID: 10411488

5

Human telomerase inhibition by substituted acridine derivatives.

Harrison RJ, Gowan SM, Kelland LR, Neidle S. Harrison RJ, et al. Among authors: gowan sm. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2463-8. doi: 10.1016/s0960-894x(99)00394-7. Bioorg Med Chem Lett. 1999. PMID: 10498189

6

Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure-activity relationships.

Read MA, Wood AA, Harrison JR, Gowan SM, Kelland LR, Dosanjh HS, Neidle S. Read MA, et al. Among authors: gowan sm. J Med Chem. 1999 Nov 4;42(22):4538-46. doi: 10.1021/jm990287e. J Med Chem. 1999. PMID: 10579817

7

Design, synthesis and evaluation of human telomerase inhibitors based upon a tetracyclic structural motif.

Perry PJ, Gowan SM, Read MA, Kelland LR, Neidle S. Perry PJ, et al. Among authors: gowan sm. Anticancer Drug Des. 1999 Aug;14(4):373-82. Anticancer Drug Des. 1999. PMID: 10625930

8

A novel inhibitor of human telomerase derived from 10H-indolo[3,2-b]quinoline.

Caprio V, Guyen B, Opoku-Boahen Y, Mann J, Gowan SM, Kelland LM, Read MA, Neidle S. Caprio V, et al. Among authors: gowan sm. Bioorg Med Chem Lett. 2000 Sep 18;10(18):2063-6. doi: 10.1016/s0960-894x(00)00378-4. Bioorg Med Chem Lett. 2000. PMID: 10999471

9

Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes.

Gowan SM, Heald R, Stevens MF, Kelland LR. Gowan SM, et al. Mol Pharmacol. 2001 Nov;60(5):981-8. doi: 10.1124/mol.60.5.981. Mol Pharmacol. 2001. PMID: 11641426

10

Antitumor polycyclic acridines. 8.(1) Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts.

Heald RA, Modi C, Cookson JC, Hutchinson I, Laughton CA, Gowan SM, Kelland LR, Stevens MF. Heald RA, et al. Among authors: gowan sm. J Med Chem. 2002 Jan 31;45(3):590-7. doi: 10.1021/jm011015q. J Med Chem. 2002. PMID: 11806711

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