Hirano H - Search Results

1

Functional evaluation of ABCB1 (P-glycoprotein) polymorphisms: high-speed screening and structure-activity relationship analyses.

Ishikawa T, Hirano H, Onishi Y, Sakurai A, Tarui S. Ishikawa T, et al. Among authors: hirano h. Drug Metab Pharmacokinet. 2004 Feb;19(1):1-14. doi: 10.2133/dmpk.19.1. Drug Metab Pharmacokinet. 2004. PMID: 15499164 Free article. Review.

2

Pharmacogenomics of drug transporters: a new approach to functional analysis of the genetic polymorphisms of ABCB1 (P-glycoprotein/MDR1).

Ishikawa T, Onishi Y, Hirano H, Oosumi K, Nagakura M, Tarui S. Ishikawa T, et al. Among authors: hirano h. Biol Pharm Bull. 2004 Jul;27(7):939-48. doi: 10.1248/bpb.27.939. Biol Pharm Bull. 2004. PMID: 15256718 Free article. Review.

3

High-speed screening of human ATP-binding cassette transporter function and genetic polymorphisms: new strategies in pharmacogenomics.

Ishikawa T, Sakurai A, Kanamori Y, Nagakura M, Hirano H, Takarada Y, Yamada K, Fukushima K, Kitajima M. Ishikawa T, et al. Among authors: hirano h. Methods Enzymol. 2005;400:485-510. doi: 10.1016/S0076-6879(05)00027-3. Methods Enzymol. 2005. PMID: 16399366

4

A new strategy of high-speed screening and quantitative structure-activity relationship analysis to evaluate human ATP-binding cassette transporter ABCG2-drug interactions.

Saito H, Hirano H, Nakagawa H, Fukami T, Oosumi K, Murakami K, Kimura H, Kouchi T, Konomi M, Tao E, Tsujikawa N, Tarui S, Nagakura M, Osumi M, Ishikawa T. Saito H, et al. Among authors: hirano h. J Pharmacol Exp Ther. 2006 Jun;317(3):1114-24. doi: 10.1124/jpet.105.099036. Epub 2006 Feb 17. J Pharmacol Exp Ther. 2006. PMID: 16489126

5

High-speed screening and QSAR analysis of human ATP-binding cassette transporter ABCB11 (bile salt export pump) to predict drug-induced intrahepatic cholestasis.

Hirano H, Kurata A, Onishi Y, Sakurai A, Saito H, Nakagawa H, Nagakura M, Tarui S, Kanamori Y, Kitajima M, Ishikawa T. Hirano H, et al. Mol Pharm. 2006 May-Jun;3(3):252-65. doi: 10.1021/mp060004w. Mol Pharm. 2006. PMID: 16749857

6

Prediction of drug-induced intrahepatic cholestasis: in vitro screening and QSAR analysis of drugs inhibiting the human bile salt export pump.

Sakurai A, Kurata A, Onishi Y, Hirano H, Ishikawa T. Sakurai A, et al. Among authors: hirano h. Expert Opin Drug Saf. 2007 Jan;6(1):71-86. doi: 10.1517/14740338.6.1.71. Expert Opin Drug Saf. 2007. PMID: 17181454 Review.

7

Quantitative structure--activity relationship analysis and molecular dynamics simulation to functionally validate nonsynonymous polymorphisms of human ABC transporter ABCB1 (P-glycoprotein/MDR1).

Sakurai A, Onishi Y, Hirano H, Seigneuret M, Obanayama K, Kim G, Liew EL, Sakaeda T, Yoshiura K, Niikawa N, Sakurai M, Ishikawa T. Sakurai A, et al. Among authors: hirano h. Biochemistry. 2007 Jul 3;46(26):7678-93. doi: 10.1021/bi700330b. Epub 2007 Jun 9. Biochemistry. 2007. PMID: 17559192

8

Emerging new technologies in Pharmacogenomics: rapid SNP detection, molecular dynamic simulation, and QSAR analysis methods to validate clinically important genetic variants of human ABC Transporter ABCB1 (P-gp/MDR1).

Ishikawa T, Sakurai A, Hirano H, Lezhava A, Sakurai M, Hayashizaki Y. Ishikawa T, et al. Among authors: hirano h. Pharmacol Ther. 2010 Apr;126(1):69-81. doi: 10.1016/j.pharmthera.2010.01.005. Epub 2010 Feb 4. Pharmacol Ther. 2010. PMID: 20138191 Review.

9

Emerging new technology: QSAR analysis and MO Calculation to characterize interactions of protein kinase inhibitors with the human ABC transporter, ABCG2 (BCRP).

Saito H, An R, Hirano H, Ishikawa T. Saito H, et al. Among authors: hirano h. Drug Metab Pharmacokinet. 2010;25(1):72-83. doi: 10.2133/dmpk.25.72. Drug Metab Pharmacokinet. 2010. PMID: 20208390 Free article. Review.

10

High-speed screening and quantitative SAR analysis of human ABC transporter ABCG2 for molecular modeling of anticancer drugs to circumvent multidrug resistance.

Saito H, Hirano H, Ishikawa T. Saito H, et al. Among authors: hirano h. Mini Rev Med Chem. 2007 Oct;7(10):1009-18. doi: 10.2174/138955707782110169. Mini Rev Med Chem. 2007. PMID: 17979803 Review.

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