Brown B - Search Results

1

Heterogeneity of the immune response to adenovirus-mediated factor VIII gene therapy in different inbred hemophilic mouse strains.

Rawle FE, Shi CX, Brown B, McKinven A, Tinlin S, Graham FL, Hough C, Lillicrap D. Rawle FE, et al. Among authors: brown b. J Gene Med. 2004 Dec;6(12):1358-68. doi: 10.1002/jgm.624. J Gene Med. 2004. PMID: 15493040

2

Factors influencing therapeutic efficacy and the host immune response to helper-dependent adenoviral gene therapy in hemophilia A mice.

Brown BD, Shi CX, Rawle FE, Tinlin S, McKinven A, Hough C, Graham FL, Lillicrap D. Brown BD, et al. J Thromb Haemost. 2004 Jan;2(1):111-8. doi: 10.1111/j.1538-7836.2004.00552.x. J Thromb Haemost. 2004. PMID: 14717974 Free article.

3

Ex vivo gene therapy for hemophilia A that enhances safe delivery and sustained in vivo factor VIII expression from lentivirally engineered endothelial progenitors.

Matsui H, Shibata M, Brown B, Labelle A, Hegadorn C, Andrews C, Hebbel RP, Galipeau J, Hough C, Lillicrap D. Matsui H, et al. Among authors: brown b. Stem Cells. 2007 Oct;25(10):2660-9. doi: 10.1634/stemcells.2006-0699. Epub 2007 Jul 5. Stem Cells. 2007. PMID: 17615271

4

A microRNA-regulated and GP64-pseudotyped lentiviral vector mediates stable expression of FVIII in a murine model of Hemophilia A.

Matsui H, Hegadorn C, Ozelo M, Burnett E, Tuttle A, Labelle A, McCray PB Jr, Naldini L, Brown B, Hough C, Lillicrap D. Matsui H, et al. Among authors: brown b. Mol Ther. 2011 Apr;19(4):723-30. doi: 10.1038/mt.2010.290. Epub 2011 Feb 1. Mol Ther. 2011. PMID: 21285959 Free PMC article.

5

Helper-dependent adenoviral vectors mediate therapeutic factor VIII expression for several months with minimal accompanying toxicity in a canine model of severe hemophilia A.

Brown BD, Shi CX, Powell S, Hurlbut D, Graham FL, Lillicrap D. Brown BD, et al. Blood. 2004 Feb 1;103(3):804-10. doi: 10.1182/blood-2003-05-1426. Epub 2003 Sep 25. Blood. 2004. PMID: 14512318 Free article.

6

A murine model for induction of long-term immunologic tolerance to factor VIII does not require persistent detectable levels of plasma factor VIII and involves contributions from Foxp3+ T regulatory cells.

Matsui H, Shibata M, Brown B, Labelle A, Hegadorn C, Andrews C, Chuah M, VandenDriessche T, Miao CH, Hough C, Lillicrap D. Matsui H, et al. Among authors: brown b. Blood. 2009 Jul 16;114(3):677-85. doi: 10.1182/blood-2009-03-202267. Epub 2009 May 20. Blood. 2009. PMID: 19458355 Free PMC article.

7

Dangerous liaisons: the role of "danger" signals in the immune response to gene therapy.

Brown BD, Lillicrap D. Brown BD, et al. Blood. 2002 Aug 15;100(4):1133-40. doi: 10.1182/blood-2001-11-0067. Blood. 2002. PMID: 12149189 Free article. Review.

8

Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors.

Chuah MK, Schiedner G, Thorrez L, Brown B, Johnston M, Gillijns V, Hertel S, Van Rooijen N, Lillicrap D, Collen D, VandenDriessche T, Kochanek S. Chuah MK, et al. Among authors: brown b. Blood. 2003 Mar 1;101(5):1734-43. doi: 10.1182/blood-2002-03-0823. Epub 2002 Oct 24. Blood. 2003. PMID: 12406898 Free article.

9

Absence of overt iron overload in two individuals compound heterozygotes for a 22 base pair deletion of exon 2 and the C282Y missense mutation of the HFE gene.

Kinkely SM, Brown BD, Lyng AT, Harrison WK, Schep GN, Goddard-Hill AC, Aubrey ME, Lillicrap D, Taylor SA. Kinkely SM, et al. Among authors: brown bd. Clin Genet. 2003 Feb;63(2):163-5. doi: 10.1034/j.1399-0004.2003.00028.x. Clin Genet. 2003. PMID: 12630967 No abstract available.

10

Bispecific antibody targeting of lipid nanoparticles.

Amabile A, Phelan M, Yu Z, Silva P, Marks A, Morla-Folch J, Sohn M, Mollaoglu G, Falcomata C, Teunissen A, Brody J, Dong Y, Brown B. Amabile A, et al. Among authors: brown b. bioRxiv [Preprint]. 2024 Dec 22:2024.12.20.629467. doi: 10.1101/2024.12.20.629467. bioRxiv. 2024. PMID: 39763831 Free PMC article. Preprint.

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