Wikel JH - Search Results

1

Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents.

Lobb KL, Hipskind PA, Aikins JA, Alvarez E, Cheung YY, Considine EL, De Dios A, Durst GL, Ferritto R, Grossman CS, Giera DD, Hollister BA, Huang Z, Iversen PW, Law KL, Li T, Lin HS, Lopez B, Lopez JE, Cabrejas LM, McCann DJ, Molero V, Reilly JE, Richett ME, Shih C, Teicher B, Wikel JH, White WT, Mader MM. Lobb KL, et al. Among authors: wikel jh. J Med Chem. 2004 Oct 21;47(22):5367-80. doi: 10.1021/jm030594r. J Med Chem. 2004. PMID: 15481975

2

Three-dimensional quantitative structure-permeability relationship analysis for a series of inhibitors of rhinovirus replication.

Ekins S, Durst GL, Stratford RE, Thorner DA, Lewis R, Loncharich RJ, Wikel JH. Ekins S, et al. Among authors: wikel jh. J Chem Inf Comput Sci. 2001 Nov-Dec;41(6):1578-86. doi: 10.1021/ci010330i. J Chem Inf Comput Sci. 2001. PMID: 11749585

3

Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 3. Synthesis and biological activities of oxazolecarboxamide-substituted omega-phenyl-omega-(3-pyridyl)alkenoic acid derivatives and related compounds.

Takeuchi K, Kohn TJ, True TA, Mais DE, Wikel JH, Utterback BG, Wyss VL, Jakubowski JA. Takeuchi K, et al. Among authors: wikel jh. J Med Chem. 1998 Dec 31;41(27):5362-74. doi: 10.1021/jm980173n. J Med Chem. 1998. PMID: 9876106

4

1,2-Dibenzamidobenzene inhibitors of human factor Xa.

Herron DK, Goodson T Jr, Wiley MR, Weir LC, Kyle JA, Yee YK, Tebbe AL, Tinsley JM, Mendel D, Masters JJ, Franciskovich JB, Sawyer JS, Beight DW, Ratz AM, Milot G, Hall SE, Klimkowski VJ, Wikel JH, Eastwood BJ, Towner RD, Gifford-Moore DS, Craft TJ, Smith GF. Herron DK, et al. Among authors: wikel jh. J Med Chem. 2000 Mar 9;43(5):859-72. doi: 10.1021/jm990326m. J Med Chem. 2000. PMID: 10715153

5

Use of conformationally restricted benzamidines as arginine surrogates in the design of platelet GPIIb-IIIa receptor antagonists.

Sall DJ, Arfsten AE, Bastian JA, Denney ML, Harms CS, McCowan JR, Morin JM Jr, Rose JW, Scarborough RM, Smyth MS, Um SL, Utterback BG, Vasileff RT, Wikel JH, Wyss VL, Jakubowski JA. Sall DJ, et al. Among authors: wikel jh. J Med Chem. 1997 Aug 29;40(18):2843-57. doi: 10.1021/jm970020k. J Med Chem. 1997. PMID: 9288166

6

Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 2. Exploring interactions at the proximal (S2) binding site.

Sall DJ, Briggs SL, Chirgadze NY, Clawson DK, Gifford-Moore DS, Klimkowski VJ, McCowan JR, Smith GF, Wikel JH. Sall DJ, et al. Among authors: wikel jh. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2527-32. doi: 10.1016/s0960-894x(98)00447-8. Bioorg Med Chem Lett. 1998. PMID: 9873574

7

Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 3. Enhancing activity by imposing conformational restriction in the C-4" side chain.

Bastian JA, Chirgadze N, Denney ML, Gifford-Moore DS, Sall DJ, Smith GF, Wikel JH. Bastian JA, et al. Among authors: wikel jh. Bioorg Med Chem Lett. 1999 Feb 8;9(3):363-8. doi: 10.1016/s0960-894x(98)00746-x. Bioorg Med Chem Lett. 1999. PMID: 10091685

8

3-Phenyl-4-hydroxyquinolin-2(1H)-ones: potent and selective antagonists at the strychnine-insensitive glycine site on the N-methyl-D-aspartate receptor complex.

McQuaid LA, Smith EC, Lodge D, Pralong E, Wikel JH, Calligaro DO, O'Malley PJ. McQuaid LA, et al. Among authors: wikel jh. J Med Chem. 1992 Sep 4;35(18):3423-5. doi: 10.1021/jm00096a019. J Med Chem. 1992. PMID: 1326635 No abstract available.

9

Comparative QSAR studies of two series of 1,4-dihydropyridines as slow calcium channel blockers.

Wikel JH, Bemis KG, Kurz K, Denney ML, Main BW, Moore RA, Smith T, Shingleton L, Holland DR. Wikel JH, et al. Drug Des Discov. 1994 Jan;11(1):1-14. Drug Des Discov. 1994. PMID: 8068815

10

Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.

Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA. Ekins S, et al. Among authors: wikel jh. Mol Pharmacol. 2002 May;61(5):964-73. doi: 10.1124/mol.61.5.964. Mol Pharmacol. 2002. PMID: 11961113

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