Shirasawa T - Search Results

1

Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement.

Morimoto A, Irie K, Murakami K, Masuda Y, Ohigashi H, Nagao M, Fukuda H, Shimizu T, Shirasawa T. Morimoto A, et al. Among authors: shirasawa t. J Biol Chem. 2004 Dec 10;279(50):52781-8. doi: 10.1074/jbc.M406262200. Epub 2004 Sep 30. J Biol Chem. 2004. PMID: 15459202 Free article.

2

Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23.

Murakami K, Irie K, Morimoto A, Ohigashi H, Shindo M, Nagao M, Shimizu T, Shirasawa T. Murakami K, et al. Among authors: shirasawa t. Biochem Biophys Res Commun. 2002 May 31;294(1):5-10. doi: 10.1016/S0006-291X(02)00430-8. Biochem Biophys Res Commun. 2002. PMID: 12054732

3

Aggregation and neurotoxicity of mutant amyloid beta (A beta) peptides with proline replacement: importance of turn formation at positions 22 and 23.

Morimoto A, Irie K, Murakami K, Ohigashi H, Shindo M, Nagao M, Shimizu T, Shirasawa T. Morimoto A, et al. Among authors: shirasawa t. Biochem Biophys Res Commun. 2002 Jul 12;295(2):306-11. doi: 10.1016/s0006-291x(02)00670-8. Biochem Biophys Res Commun. 2002. PMID: 12150948

4

Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease.

Murakami K, Irie K, Morimoto A, Ohigashi H, Shindo M, Nagao M, Shimizu T, Shirasawa T. Murakami K, et al. Among authors: shirasawa t. J Biol Chem. 2003 Nov 14;278(46):46179-87. doi: 10.1074/jbc.M301874200. Epub 2003 Aug 27. J Biol Chem. 2003. PMID: 12944403 Free article.

5

Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR.

Masuda Y, Irie K, Murakami K, Ohigashi H, Ohashi R, Takegoshi K, Shimizu T, Shirasawa T. Masuda Y, et al. Among authors: shirasawa t. Bioorg Med Chem. 2005 Dec 15;13(24):6803-9. doi: 10.1016/j.bmc.2005.07.071. Epub 2005 Sep 22. Bioorg Med Chem. 2005. PMID: 16182533

6

Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's disease.

Irie K, Murakami K, Masuda Y, Morimoto A, Ohigashi H, Ohashi R, Takegoshi K, Nagao M, Shimizu T, Shirasawa T. Irie K, et al. Among authors: shirasawa t. J Biosci Bioeng. 2005 May;99(5):437-47. doi: 10.1263/jbb.99.437. J Biosci Bioeng. 2005. PMID: 16233815 Review.

7

Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease.

Murakami K, Irie K, Ohigashi H, Hara H, Nagao M, Shimizu T, Shirasawa T. Murakami K, et al. Among authors: shirasawa t. J Am Chem Soc. 2005 Nov 2;127(43):15168-74. doi: 10.1021/ja054041c. J Am Chem Soc. 2005. PMID: 16248658

8

Isomerization and/or racemization at Asp23 of Abeta42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro.

Murakami K, Uno M, Masuda Y, Shimizu T, Shirasawa T, Irie K. Murakami K, et al. Among authors: shirasawa t. Biochem Biophys Res Commun. 2008 Feb 15;366(3):745-51. doi: 10.1016/j.bbrc.2007.12.009. Epub 2007 Dec 17. Biochem Biophys Res Commun. 2008. PMID: 18078812

9

Verification of the C-terminal intramolecular beta-sheet in Abeta42 aggregates using solid-state NMR: implications for potent neurotoxicity through the formation of radicals.

Masuda Y, Uemura S, Nakanishi A, Ohashi R, Takegoshi K, Shimizu T, Shirasawa T, Irie K. Masuda Y, et al. Among authors: shirasawa t. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3206-10. doi: 10.1016/j.bmcl.2008.04.060. Epub 2008 Apr 26. Bioorg Med Chem Lett. 2008. PMID: 18468894

10

Verification of the intermolecular parallel beta-sheet in E22K-Abeta42 aggregates by solid-state NMR using rotational resonance: implications for the supramolecular arrangement of the toxic conformer of Abeta42.

Masuda Y, Nakanishi A, Ohashi R, Takegoshi K, Shimizu T, Shirasawa T, Irie K. Masuda Y, et al. Among authors: shirasawa t. Biosci Biotechnol Biochem. 2008 Aug;72(8):2170-5. doi: 10.1271/bbb.80250. Epub 2008 Aug 7. Biosci Biotechnol Biochem. 2008. PMID: 18685204 Free article.

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