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AKAP-Lbc nucleates a protein kinase D activation scaffold.
Carnegie GK, Smith FD, McConnachie G, Langeberg LK, Scott JD. Carnegie GK, et al. Mol Cell. 2004 Sep 24;15(6):889-99. doi: 10.1016/j.molcel.2004.09.015. Mol Cell. 2004. PMID: 15383279 Free article.
AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway.
Carnegie GK, Soughayer J, Smith FD, Pedroja BS, Zhang F, Diviani D, Bristow MR, Kunkel MT, Newton AC, Langeberg LK, Scott JD. Carnegie GK, et al. Mol Cell. 2008 Oct 24;32(2):169-79. doi: 10.1016/j.molcel.2008.08.030. Mol Cell. 2008. PMID: 18951085 Free PMC article.
Src homology 2 domain-containing phosphatase 2 (Shp2) is a component of the A-kinase-anchoring protein (AKAP)-Lbc complex and is inhibited by protein kinase A (PKA) under pathological hypertrophic conditions in the heart.
Burmeister BT, Taglieri DM, Wang L, Carnegie GK. Burmeister BT, et al. Among authors: carnegie gk. J Biol Chem. 2012 Nov 23;287(48):40535-46. doi: 10.1074/jbc.M112.385641. Epub 2012 Oct 8. J Biol Chem. 2012. PMID: 23045525 Free PMC article.
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