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Page 1
Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation.
Hopkins C, Neuenschwander K, Scotese A, Jackson S, Nieduzak T, Pauls H, Liang G, Sides K, Cramer D, Cairns J, Maignan S, Mathieu M. Hopkins C, et al. Among authors: nieduzak t. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4819-23. doi: 10.1016/j.bmcl.2004.07.051. Bioorg Med Chem Lett. 2004. PMID: 15341931
Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase.
Jackson SA, Sahni S, Lee L, Luo Y, Nieduzak TR, Liang G, Chiang Y, Collar N, Fink D, He W, Laoui A, Merrill J, Boffey R, Crackett P, Rees B, Wong M, Guilloteau JP, Mathieu M, Rebello SS. Jackson SA, et al. Among authors: nieduzak tr. Bioorg Med Chem. 2005 Apr 15;13(8):2723-39. doi: 10.1016/j.bmc.2005.02.036. Bioorg Med Chem. 2005. PMID: 15781384
A conformationally constrained inhibitor with an enhanced potency for β-tryptase and stability against semicarbazide-sensitive amine oxidase (SSAO).
Liang G, Choi-Sledeski YM, Poli G, Chen X, Shum P, Minnich A, Wang Q, Tsay J, Sides K, Cairns J, Stoklosa G, Nieduzak T, Zhao Z, Wang J, Vaz RJ. Liang G, et al. Among authors: nieduzak t. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6721-4. doi: 10.1016/j.bmcl.2010.08.141. Epub 2010 Sep 6. Bioorg Med Chem Lett. 2010. PMID: 20855210
Hydroxyoxazolidines as alpha-aminoacetaldehye equivalents: novel inhibitors of calpain.
Peet NP, Kim HO, Marquart AL, Angelastro MR, Nieduzak TR, White JN, Friedrich D, Flynn GA, Webster ME, Vaz RJ, Linnik MD, Koehl JR, Mehdi S, Bey P, Emary B, Hwang KK. Peet NP, et al. Among authors: nieduzak tr. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2365-70. doi: 10.1016/s0960-894x(99)00391-1. Bioorg Med Chem Lett. 1999. PMID: 10476870