Böttcher H - Search Results

1

Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors.

Heinrich T, Böttcher H, Gericke R, Bartoszyk GD, Anzali S, Seyfried CA, Greiner HE, Van Amsterdam C. Heinrich T, et al. Among authors: bottcher h. J Med Chem. 2004 Sep 9;47(19):4684-92. doi: 10.1021/jm040793q. J Med Chem. 2004. PMID: 15341484

2

EMD 281014, a new selective serotonin 5-HT2A receptor antagonist.

Bartoszyk GD, van Amsterdam C, Böttcher H, Seyfried CA. Bartoszyk GD, et al. Among authors: bottcher h. Eur J Pharmacol. 2003 Jul 25;473(2-3):229-30. doi: 10.1016/s0014-2999(03)01992-7. Eur J Pharmacol. 2003. PMID: 12892843

3

Dual 5-HT1A agonists and 5-HT re-uptake inhibitors by combination of indole-butyl-amine and chromenonyl-piperazine structural elements in a single molecular entity.

Heinrich T, Böttcher H, Schiemann K, Hölzemann G, Schwarz M, Bartoszyk GD, van Amsterdam C, Greiner HE, Seyfried CA. Heinrich T, et al. Among authors: bottcher h. Bioorg Med Chem. 2004 Sep 15;12(18):4843-52. doi: 10.1016/j.bmc.2004.07.014. Bioorg Med Chem. 2004. PMID: 15336263

4

Indolebutylamines as selective 5-HT(1A) agonists.

Heinrich T, Böttcher H, Bartoszyk GD, Greiner HE, Seyfried CA, Van Amsterdam C. Heinrich T, et al. Among authors: bottcher h. J Med Chem. 2004 Sep 9;47(19):4677-83. doi: 10.1021/jm040792y. J Med Chem. 2004. PMID: 15341483

5

A new synthesis of indole 5-carboxylic acids and 6-hydroxy-indole-5-carboxylic acids in the preparation of an o-hydroxylated metabolite of vilazodone.

Heinrich T, Böttcher H. Heinrich T, et al. Among authors: bottcher h. Bioorg Med Chem Lett. 2004 May 17;14(10):2681-4. doi: 10.1016/j.bmcl.2004.01.110. Bioorg Med Chem Lett. 2004. PMID: 15109678

6

Synthesis and dopaminergic activity of some 3-(1,2,3,6-tetrahydro-1-pyridylalkyl)indoles. A novel conformational model to explain structure-activity relationships.

Böttcher H, Barnickel G, Hausberg HH, Haase AF, Seyfried CA, Eiermann V. Böttcher H, et al. J Med Chem. 1992 Oct 30;35(22):4020-6. doi: 10.1021/jm00100a006. J Med Chem. 1992. PMID: 1359142

7

SAR of novel biarylmethylamine dopamine D4 receptor ligands.

Arlt M, Böttcher H, Riethmüller A, Schneider G, Bartoszyk GD, Greiner H, Seyfried CA. Arlt M, et al. Among authors: bottcher h. Bioorg Med Chem Lett. 1998 Aug 4;8(15):2033-8. doi: 10.1016/s0960-894x(98)00361-8. Bioorg Med Chem Lett. 1998. PMID: 9873481

8

5-HT reuptake inhibitors with 5-HT(1B/1D) antagonistic activity: a new approach toward efficient antidepressants.

Matzen L, van Amsterdam C, Rautenberg W, Greiner HE, Harting J, Seyfried CA, Böttcher H. Matzen L, et al. Among authors: bottcher h. J Med Chem. 2000 Mar 23;43(6):1149-57. doi: 10.1021/jm9811054. J Med Chem. 2000. PMID: 10737747

9

2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.

Mattsson C, Sonesson C, Sandahl A, Greiner HE, Gassen M, Plaschke J, Leibrock J, Böttcher H. Mattsson C, et al. Among authors: bottcher h. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4230-4. doi: 10.1016/j.bmcl.2005.06.067. Bioorg Med Chem Lett. 2005. PMID: 16055331

10

1-(1-phenethylpiperidin-4-yl)-1-phenylethanols as potent and highly selective 5-HT2A antagonists.

Heinrich T, Böttcher H, Prücher H, Gottschlich R, Ackermann KA, van Amsterdam C. Heinrich T, et al. Among authors: bottcher h. ChemMedChem. 2006 Feb;1(2):245-55. doi: 10.1002/cmdc.200500023. ChemMedChem. 2006. PMID: 16892357

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