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A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.
Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Müller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM. Leissring MA, et al. Among authors: murphy mp. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4697-702. doi: 10.1073/pnas.072033799. Epub 2002 Mar 26. Proc Natl Acad Sci U S A. 2002. PMID: 11917117 Free PMC article.
Peptide-based, irreversible inhibitors of gamma-secretase activity.
Piper SC, Amtul Z, Galiñanes-Garcia L, Howard VG, Ziani-Cherif C, McLendon C, Rochette MJ, Fauq A, Golde TE, Murphy MP. Piper SC, et al. Among authors: murphy mp. Biochem Biophys Res Commun. 2003 Jun 6;305(3):529-33. doi: 10.1016/s0006-291x(03)00828-3. Biochem Biophys Res Commun. 2003. PMID: 12763025
An empirical model of gamma-secretase activity.
Murphy MP, Wang R, Fraser PE, Fauq A, Golde TE. Murphy MP, et al. Ann N Y Acad Sci. 2000;920:233-40. doi: 10.1111/j.1749-6632.2000.tb06928.x. Ann N Y Acad Sci. 2000. PMID: 11193156
Overexpression of nicastrin increases Abeta production.
Murphy MP, Das P, Nyborg AC, Rochette MJ, Dodson MW, Loosbrock NM, Souder TM, McLendon C, Merit SL, Piper SC, Jansen KR, Golde TE. Murphy MP, et al. FASEB J. 2003 Jun;17(9):1138-40. doi: 10.1096/fj.02-1050fje. Epub 2003 Apr 8. FASEB J. 2003. PMID: 12692078
810 results