Davies J - Search Results

1

Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore.

O'Neill PM, Mukhtar A, Ward SA, Bickley JF, Davies J, Bachi MD, Stocks PA. O'Neill PM, et al. Among authors: davies j. Org Lett. 2004 Sep 2;6(18):3035-8. doi: 10.1021/ol0492142. Org Lett. 2004. PMID: 15330581

2

Diels-Alder/thiol-olefin co-oxygenation approach to antimalarials incorporating the 2,3-dioxabicyclo[3.3.1]nonane pharmacophore.

O'Neill PM, Verissimo E, Ward SA, Davies J, Korshin EE, Araujo N, Pugh MD, Cristiano ML, Stocks PA, Bachi MD. O'Neill PM, et al. Among authors: davies j. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2991-5. doi: 10.1016/j.bmcl.2006.02.059. Epub 2006 Mar 9. Bioorg Med Chem Lett. 2006. PMID: 16527481

3

Synthesis of 1,2,4-trioxepanes via application of thiol-olefin co-oxygenation methodology.

Amewu R, Stachulski AV, Berry NG, Ward SA, Davies J, Labat G, Rossignol JF, O'Neill PM. Amewu R, et al. Among authors: davies j. Bioorg Med Chem Lett. 2006 Dec 1;16(23):6124-30. doi: 10.1016/j.bmcl.2006.08.098. Epub 2006 Sep 15. Bioorg Med Chem Lett. 2006. PMID: 16978862

4

Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin.

Amewu R, Stachulski AV, Ward SA, Berry NG, Bray PG, Davies J, Labat G, Vivas L, O'Neill PM. Amewu R, et al. Among authors: davies j. Org Biomol Chem. 2006 Dec 21;4(24):4431-6. doi: 10.1039/b613565j. Epub 2006 Nov 3. Org Biomol Chem. 2006. PMID: 17268634

5

Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols.

Amewu R, Gibbons P, Mukhtar A, Stachulski AV, Ward SA, Hall C, Rimmer K, Davies J, Vivas L, Bacsa J, Mercer AE, Nixon G, Stocks PA, O'Neill PM. Amewu R, et al. Among authors: davies j. Org Biomol Chem. 2010 May 7;8(9):2068-77. doi: 10.1039/b924319d. Epub 2010 Mar 3. Org Biomol Chem. 2010. PMID: 20401383 Free article.

6

Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins.

O'Neill PM, Rawe SL, Borstnik K, Miller A, Ward SA, Bray PG, Davies J, Oh CH, Posner GH. O'Neill PM, et al. Among authors: davies j. Chembiochem. 2005 Nov;6(11):2048-54. doi: 10.1002/cbic.200500048. Chembiochem. 2005. PMID: 16222725

7

Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues.

Hindley S, Ward SA, Storr RC, Searle NL, Bray PG, Park BK, Davies J, O'Neill PM. Hindley S, et al. Among authors: davies j. J Med Chem. 2002 Feb 28;45(5):1052-63. doi: 10.1021/jm0109816. J Med Chem. 2002. PMID: 11855985

8

Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin.

Jeyadevan JP, Bray PG, Chadwick J, Mercer AE, Byrne A, Ward SA, Park BK, Williams DP, Cosstick R, Davies J, Higson AP, Irving E, Posner GH, O'Neill PM. Jeyadevan JP, et al. Among authors: davies j. J Med Chem. 2004 Feb 26;47(5):1290-8. doi: 10.1021/jm030974c. J Med Chem. 2004. PMID: 14971909

9

Design and synthesis of endoperoxide antimalarial prodrug models.

O'Neill PM, Stocks PA, Pugh MD, Araujo NC, Korshin EE, Bickley JF, Ward SA, Bray PG, Pasini E, Davies J, Verissimo E, Bachi MD. O'Neill PM, et al. Among authors: davies j. Angew Chem Int Ed Engl. 2004 Aug 13;43(32):4193-7. doi: 10.1002/anie.200453859. Angew Chem Int Ed Engl. 2004. PMID: 15307085 No abstract available.

10

Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.

Ellis GL, Amewu R, Sabbani S, Stocks PA, Shone A, Stanford D, Gibbons P, Davies J, Vivas L, Charnaud S, Bongard E, Hall C, Rimmer K, Lozanom S, Jesús M, Gargallo D, Ward SA, O'Neill PM. Ellis GL, et al. Among authors: davies j. J Med Chem. 2008 Apr 10;51(7):2170-7. doi: 10.1021/jm701435h. Epub 2008 Mar 15. J Med Chem. 2008. PMID: 18341274

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