Locatelli GA - Search Results

1

HIV-1 reverse transcriptase inhibitors: current issues and future perspectives.

Locatelli GA, Cancio R, Spadari S, Maga G. Locatelli GA, et al. Curr Drug Metab. 2004 Aug;5(4):283-90. doi: 10.2174/1389200043335504. Curr Drug Metab. 2004. PMID: 15320700 Review.

2

Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex.

Locatelli GA, Campiani G, Cancio R, Morelli E, Ramunno A, Gemma S, Hübscher U, Spadari S, Maga G. Locatelli GA, et al. Antimicrob Agents Chemother. 2004 May;48(5):1570-80. doi: 10.1128/AAC.48.5.1570-1580.2004. Antimicrob Agents Chemother. 2004. PMID: 15105107 Free PMC article.

3

Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz.

Crespan E, Locatelli GA, Cancio R, Hübscher U, Spadari S, Maga G. Crespan E, et al. Among authors: locatelli ga. Antimicrob Agents Chemother. 2005 Jan;49(1):342-9. doi: 10.1128/AAC.49.1.342-349.2005. Antimicrob Agents Chemother. 2005. PMID: 15616314 Free PMC article.

4

The stereoselective targeting of a specific enzyme-substrate complex is the molecular mechanism for the synergic inhibition of HIV-1 reverse transcriptase by (R)-(-)-PPO464: a novel generation of nonnucleoside inhibitors.

Maga G, Ramunno A, Nacci V, Locatelli GA, Spadari S, Fiorini I, Baldanti F, Paolucci S, Zavattoni M, Bergamini A, Galletti B, Muck S, Hubscher U, Giorgi G, Guiso G, Caccia S, Campiani G. Maga G, et al. Among authors: locatelli ga. J Biol Chem. 2001 Nov 30;276(48):44653-62. doi: 10.1074/jbc.M106702200. Epub 2001 Sep 25. J Biol Chem. 2001. PMID: 11572864 Free article.

5

Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells.

Locatelli GA, Di Santo R, Crespan E, Costi R, Roux A, Hübscher U, Shevelev I, Blanca G, Villani G, Spadari S, Maga G. Locatelli GA, et al. Mol Pharmacol. 2005 Aug;68(2):538-50. doi: 10.1124/mol.105.013326. Epub 2005 May 18. Mol Pharmacol. 2005. PMID: 15901847

6

Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663.

Maga G, Gemma S, Fattorusso C, Locatelli GA, Butini S, Persico M, Kukreja G, Romano MP, Chiasserini L, Savini L, Novellino E, Nacci V, Spadari S, Campiani G. Maga G, et al. Among authors: locatelli ga. Biochemistry. 2005 Jul 19;44(28):9637-44. doi: 10.1021/bi047437u. Biochemistry. 2005. PMID: 16008349

7

Hepatitis C virus NS3 ATPase/helicase: an ATP switch regulates the cooperativity among the different substrate binding sites.

Locatelli GA, Spadari S, Maga G. Locatelli GA, et al. Biochemistry. 2002 Aug 13;41(32):10332-42. doi: 10.1021/bi026082g. Biochemistry. 2002. PMID: 12162749

8

Hepatitis C virus NS3 NTPase/helicase: different stereoselectivity in nucleoside triphosphate utilisation suggests that NTPase and helicase activities are coupled by a nucleotide-dependent rate limiting step.

Locatelli GA, Gosselin G, Spadari S, Maga G. Locatelli GA, et al. J Mol Biol. 2001 Nov 2;313(4):683-94. doi: 10.1006/jmbi.2001.5088. J Mol Biol. 2001. PMID: 11697897

9

DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A.

Maga G, Ramadan K, Locatelli GA, Shevelev I, Spadari S, Hübscher U. Maga G, et al. Among authors: locatelli ga. J Biol Chem. 2005 Jan 21;280(3):1971-81. doi: 10.1074/jbc.M411650200. Epub 2004 Nov 10. J Biol Chem. 2005. PMID: 15537631 Free article.

10

Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants.

Locatelli GA, Savio M, Forti L, Shevelev I, Ramadan K, Stivala LA, Vannini V, Hübscher U, Spadari S, Maga G. Locatelli GA, et al. Biochem J. 2005 Jul 15;389(Pt 2):259-68. doi: 10.1042/BJ20050094. Biochem J. 2005. PMID: 15773817 Free PMC article.

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