Brodkin J - Search Results

1

The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety.

Busse CS, Brodkin J, Tattersall D, Anderson JJ, Warren N, Tehrani L, Bristow LJ, Varney MA, Cosford ND. Busse CS, et al. Among authors: brodkin j. Neuropsychopharmacology. 2004 Nov;29(11):1971-9. doi: 10.1038/sj.npp.1300540. Neuropsychopharmacology. 2004. PMID: 15305166

2

Reduced stress-induced hyperthermia in mGluR5 knockout mice.

Brodkin J, Bradbury M, Busse C, Warren N, Bristow LJ, Varney MA. Brodkin J, et al. Eur J Neurosci. 2002 Dec;16(11):2241-4. doi: 10.1046/j.1460-9568.2002.02294.x. Eur J Neurosci. 2002. PMID: 12473093

3

Anxiolytic-like activity of the mGluR5 antagonist MPEP: a comparison with diazepam and buspirone.

Brodkin J, Busse C, Sukoff SJ, Varney MA. Brodkin J, et al. Pharmacol Biochem Behav. 2002 Sep;73(2):359-66. doi: 10.1016/s0091-3057(02)00828-6. Pharmacol Biochem Behav. 2002. PMID: 12117590

4

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity.

Cosford ND, Tehrani L, Roppe J, Schweiger E, Smith ND, Anderson J, Bristow L, Brodkin J, Jiang X, McDonald I, Rao S, Washburn M, Varney MA. Cosford ND, et al. Among authors: brodkin j. J Med Chem. 2003 Jan 16;46(2):204-6. doi: 10.1021/jm025570j. J Med Chem. 2003. PMID: 12519057

5

5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity.

Roppe JR, Wang B, Huang D, Tehrani L, Kamenecka T, Schweiger EJ, Anderson JJ, Brodkin J, Jiang X, Cramer M, Chung J, Reyes-Manalo G, Munoz B, Cosford ND. Roppe JR, et al. Among authors: brodkin j. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3993-6. doi: 10.1016/j.bmcl.2004.05.037. Bioorg Med Chem Lett. 2004. PMID: 15225713

6

Discovery of novel modulators of metabotropic glutamate receptor subtype-5.

Wang B, Vernier JM, Rao S, Chung J, Anderson JJ, Brodkin JD, Jiang X, Gardner MF, Yang X, Munoz B. Wang B, et al. Among authors: brodkin jd. Bioorg Med Chem. 2004 Jan 2;12(1):17-21. doi: 10.1016/j.bmc.2003.10.021. Bioorg Med Chem. 2004. PMID: 14697765

7

Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity.

Roppe J, Smith ND, Huang D, Tehrani L, Wang B, Anderson J, Brodkin J, Chung J, Jiang X, King C, Munoz B, Varney MA, Prasit P, Cosford ND. Roppe J, et al. Among authors: brodkin j. J Med Chem. 2004 Sep 9;47(19):4645-8. doi: 10.1021/jm049828c. J Med Chem. 2004. PMID: 15341479

8

GABA-A and 5-HT1A receptor agonists block expression of fear-potentiated startle in mice.

Risbrough VB, Brodkin JD, Geyer MA. Risbrough VB, et al. Among authors: brodkin jd. Neuropsychopharmacology. 2003 Apr;28(4):654-63. doi: 10.1038/sj.npp.1300079. Epub 2002 Oct 3. Neuropsychopharmacology. 2003. PMID: 12655310

9

Antidepressant-like effects of the subtype-selective nicotinic acetylcholine receptor agonist, SIB-1508Y, in the learned helplessness rat model of depression.

Ferguson SM, Brodkin JD, Lloyd GK, Menzaghi F. Ferguson SM, et al. Among authors: brodkin jd. Psychopharmacology (Berl). 2000 Oct;152(3):295-303. doi: 10.1007/s002130000531. Psychopharmacology (Berl). 2000. PMID: 11105940

10

Communicating synergism in drug combination studies.

Brodkin J, Shannon HE. Brodkin J, et al. Arzneimittelforschung. 2000 Aug;50(8):765-7. doi: 10.1055/s-0031-1300285. Arzneimittelforschung. 2000. PMID: 10994162

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