Rosen N - Search Results

1

Development of a fluorescence polarization assay for the molecular chaperone Hsp90.

Kim J, Felts S, Llauger L, He H, Huezo H, Rosen N, Chiosis G. Kim J, et al. Among authors: rosen n. J Biomol Screen. 2004 Aug;9(5):375-81. doi: 10.1177/1087057104265995. J Biomol Screen. 2004. PMID: 15296636

2

Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90.

Schneider C, Sepp-Lorenzino L, Nimmesgern E, Ouerfelli O, Danishefsky S, Rosen N, Hartl FU. Schneider C, et al. Among authors: rosen n. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14536-41. doi: 10.1073/pnas.93.25.14536. Proc Natl Acad Sci U S A. 1996. PMID: 8962087 Free PMC article.

3

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent.

Stebbins CE, Russo AA, Schneider C, Rosen N, Hartl FU, Pavletich NP. Stebbins CE, et al. Among authors: rosen n. Cell. 1997 Apr 18;89(2):239-50. doi: 10.1016/s0092-8674(00)80203-2. Cell. 1997. PMID: 9108479 Free article.

4

Synthesis and evaluation of geldanamycin-estradiol hybrids.

Kuduk SD, Zheng FF, Sepp-Lorenzino L, Rosen N, Danishefsky SJ. Kuduk SD, et al. Among authors: rosen n. Bioorg Med Chem Lett. 1999 May 3;9(9):1233-8. doi: 10.1016/s0960-894x(99)00185-7. Bioorg Med Chem Lett. 1999. PMID: 10340605

5

Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases.

Zheng FF, Kuduk SD, Chiosis G, Münster PN, Sepp-Lorenzino L, Danishefsky SJ, Rosen N. Zheng FF, et al. Among authors: rosen n. Cancer Res. 2000 Apr 15;60(8):2090-4. Cancer Res. 2000. PMID: 10786665

6

Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest.

Srethapakdi M, Liu F, Tavorath R, Rosen N. Srethapakdi M, et al. Among authors: rosen n. Cancer Res. 2000 Jul 15;60(14):3940-6. Cancer Res. 2000. PMID: 10919672

7

LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family.

Chiosis G, Rosen N, Sepp-Lorenzino L. Chiosis G, et al. Among authors: rosen n. Bioorg Med Chem Lett. 2001 Apr 9;11(7):909-13. doi: 10.1016/s0960-894x(01)00099-3. Bioorg Med Chem Lett. 2001. PMID: 11294389

8

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells.

Chiosis G, Timaul MN, Lucas B, Munster PN, Zheng FF, Sepp-Lorenzino L, Rosen N. Chiosis G, et al. Among authors: rosen n. Chem Biol. 2001 Mar;8(3):289-99. doi: 10.1016/s1074-5521(01)00015-1. Chem Biol. 2001. PMID: 11306353

9

Facile synthesis of a library of 9-alkyl-8-benzyl-9H-purin-6-ylamine derivatives.

Lucas B, Rosen N, Chiosis G. Lucas B, et al. Among authors: rosen n. J Comb Chem. 2001 Nov-Dec;3(6):518-20. doi: 10.1021/cc010017t. J Comb Chem. 2001. PMID: 11703144 No abstract available.

10

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function.

Basso AD, Solit DB, Chiosis G, Giri B, Tsichlis P, Rosen N. Basso AD, et al. Among authors: rosen n. J Biol Chem. 2002 Oct 18;277(42):39858-66. doi: 10.1074/jbc.M206322200. Epub 2002 Aug 9. J Biol Chem. 2002. PMID: 12176997 Free article.

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