Gullbo J - Search Results

1

Antitumor efficacy and acute toxicity of the novel dipeptide melphalanyl-p-L-fluorophenylalanine ethyl ester (J1) in vivo.

Gullbo J, Lindhagen E, Bashir-Hassan S, Tullberg M, Ehrsson H, Lewensohn R, Nygren P, De La Torre M, Luthman K, Larsson R. Gullbo J, et al. Invest New Drugs. 2004 Nov;22(4):411-20. doi: 10.1023/B:DRUG.0000036683.10945.bb. Invest New Drugs. 2004. PMID: 15292711

2

Antitumor activity of the alkylating oligopeptides J1 (L-melphalanyl-p-L-fluorophenylalanine ethyl ester) and P2 (L-prolyl-m-L-sarcolysyl-p-L-fluorophenylalanine ethyl ester): comparison with melphalan.

Gullbo J, Dhar S, Luthman K, Ehrsson H, Lewensohn R, Nygren P, Larsson R. Gullbo J, et al. Anticancer Drugs. 2003 Sep;14(8):617-24. doi: 10.1097/00001813-200309000-00006. Anticancer Drugs. 2003. PMID: 14501383

3

Activity of hydrolytic enzymes in tumour cells is a determinant for anti-tumour efficacy of the melphalan containing prodrug J1.

Gullbo J, Wickström M, Tullberg M, Ehrsson H, Lewensohn R, Nygren P, Luthman K, Larsson R. Gullbo J, et al. J Drug Target. 2003 Jul;11(6):355-63. doi: 10.1080/10611860310001647140. J Drug Target. 2003. PMID: 14668056

4

Antitumor activity of the novel melphalan containing tripeptide J3 (L-prolyl-L-melphalanyl-p-L-fluorophenylalanine ethyl ester): comparison with its m-L-sarcolysin analogue P2.

Gullbo J, Wallinder C, Tullberg M, Lövborg H, Ehrsson H, Lewensohn R, Nygren P, Luthman K, Larsson R. Gullbo J, et al. Mol Cancer Ther. 2003 Dec;2(12):1331-9. Mol Cancer Ther. 2003. PMID: 14707274

5

Structure-activity relationship for alkylating dipeptide nitrogen mustard derivatives.

Gullbo J, Tullberg M, Våbenø J, Ehrsson H, Lewensohn R, Nygren P, Larsson R, Luthman K. Gullbo J, et al. Oncol Res. 2003;14(3):113-32. doi: 10.3727/000000003771013071. Oncol Res. 2003. PMID: 14760861

6

The novel melphalan prodrug J1 inhibits neuroblastoma growth in vitro and in vivo.

Wickström M, Johnsen JI, Ponthan F, Segerström L, Sveinbjörnsson B, Lindskog M, Lövborg H, Viktorsson K, Lewensohn R, Kogner P, Larsson R, Gullbo J. Wickström M, et al. Among authors: gullbo j. Mol Cancer Ther. 2007 Sep;6(9):2409-17. doi: 10.1158/1535-7163.MCT-07-0156. Mol Cancer Ther. 2007. PMID: 17876040

7

The novel alkylating prodrug J1: diagnosis directed activity profile ex vivo and combination analyses in vitro.

Wickström M, Haglund C, Lindman H, Nygren P, Larsson R, Gullbo J. Wickström M, et al. Among authors: gullbo j. Invest New Drugs. 2008 Jun;26(3):195-204. doi: 10.1007/s10637-007-9092-1. Epub 2007 Oct 6. Invest New Drugs. 2008. PMID: 17922077

8

First-in-human, phase I/IIa clinical study of the peptidase potentiated alkylator melflufen administered every three weeks to patients with advanced solid tumor malignancies.

Berglund Å, Ullén A, Lisyanskaya A, Orlov S, Hagberg H, Tholander B, Lewensohn R, Nygren P, Spira J, Harmenberg J, Jerling M, Alvfors C, Ringbom M, Nordström E, Söderlind K, Gullbo J. Berglund Å, et al. Among authors: gullbo j. Invest New Drugs. 2015 Dec;33(6):1232-41. doi: 10.1007/s10637-015-0299-2. Epub 2015 Nov 10. Invest New Drugs. 2015. PMID: 26553306 Clinical Trial.

9

Cytotoxic activity of a new lipid formulation of doxorubicin in cell lines and primary tumor cells.

Gullbo J, Arsenau D, Grundmark B, Alvfors C, Larsson R, Lindhagen E. Gullbo J, et al. Anticancer Res. 2002 Nov-Dec;22(6C):4191-8. Anticancer Res. 2002. PMID: 12553055

10

Development and characterization of two human tumor sublines expressing high-grade resistance to the cyanoguanidine CHS 828.

Gullbo J, Lövborg H, Dhar S, Lukinius A, Oberg F, Nilsson K, Björkling F, Binderup L, Nygren P, Larsson R. Gullbo J, et al. Anticancer Drugs. 2004 Jan;15(1):45-54. doi: 10.1097/00001813-200401000-00008. Anticancer Drugs. 2004. PMID: 15090743

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