Brown S - Search Results

1

RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B.

Wu J, Brown S, Xuong NH, Taylor SS. Wu J, et al. Among authors: brown s. Structure. 2004 Jun;12(6):1057-65. doi: 10.1016/j.str.2004.03.022. Structure. 2004. PMID: 15274925 Free article.

2

PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity.

Wu J, Brown SH, von Daake S, Taylor SS. Wu J, et al. Among authors: brown sh. Science. 2007 Oct 12;318(5848):274-9. doi: 10.1126/science.1146447. Science. 2007. PMID: 17932298 Free PMC article.

3

R-subunit isoform specificity in protein kinase A: distinct features of protein interfaces in PKA types I and II by amide H/2H exchange mass spectrometry.

Anand GS, Hotchko M, Brown SH, Ten Eyck LF, Komives EA, Taylor SS. Anand GS, et al. Among authors: brown sh. J Mol Biol. 2007 Nov 23;374(2):487-99. doi: 10.1016/j.jmb.2007.09.035. Epub 2007 Sep 20. J Mol Biol. 2007. PMID: 17942118 Free PMC article.

4

Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design.

Taylor SS, Kim C, Cheng CY, Brown SH, Wu J, Kannan N. Taylor SS, et al. Among authors: brown sh. Biochim Biophys Acta. 2008 Jan;1784(1):16-26. doi: 10.1016/j.bbapap.2007.10.002. Epub 2007 Oct 12. Biochim Biophys Acta. 2008. PMID: 17996741 Free PMC article. Review.

5

Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures.

Brown SH, Wu J, Kim C, Alberto K, Taylor SS. Brown SH, et al. J Mol Biol. 2009 Nov 13;393(5):1070-82. doi: 10.1016/j.jmb.2009.09.014. Epub 2009 Sep 11. J Mol Biol. 2009. PMID: 19748511 Free PMC article.

6

Implementing fluorescence anisotropy screening and crystallographic analysis to define PKA isoform-selective activation by cAMP analogs.

Brown SH, Cheng CY, Saldanha SA, Wu J, Cottam HB, Sankaran B, Taylor SS. Brown SH, et al. ACS Chem Biol. 2013 Oct 18;8(10):2164-72. doi: 10.1021/cb400247t. Epub 2013 Sep 10. ACS Chem Biol. 2013. PMID: 23978166 Free PMC article.

7

Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions.

Vigil D, Blumenthal DK, Heller WT, Brown S, Canaves JM, Taylor SS, Trewhella J. Vigil D, et al. Among authors: brown s. J Mol Biol. 2004 Apr 9;337(5):1183-94. doi: 10.1016/j.jmb.2004.02.028. J Mol Biol. 2004. PMID: 15046986

8

Differential effects of substrate on type I and type II PKA holoenzyme dissociation.

Vigil D, Blumenthal DK, Brown S, Taylor SS, Trewhella J. Vigil D, et al. Among authors: brown s. Biochemistry. 2004 May 18;43(19):5629-36. doi: 10.1021/bi0499157. Biochemistry. 2004. PMID: 15134437 Free article.

9

NMR assignment of the cAMP-binding domain A of the PKA regulatory subunit.

Esposito V, Sjoberg T, Das R, Brown S, Taylor SS, Melacini G. Esposito V, et al. Among authors: brown s. J Biomol NMR. 2006;36 Suppl 1:64. doi: 10.1007/s10858-006-9050-9. Epub 2006 Oct 3. J Biomol NMR. 2006. PMID: 17016670 No abstract available.

10

C subunits binding to the protein kinase A RI alpha dimer induce a large conformational change.

Heller WT, Vigil D, Brown S, Blumenthal DK, Taylor SS, Trewhella J. Heller WT, et al. Among authors: brown s. J Biol Chem. 2004 Apr 30;279(18):19084-90. doi: 10.1074/jbc.M313405200. Epub 2004 Feb 25. J Biol Chem. 2004. PMID: 14985329 Free article.

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