Huang W - Search Results

1

Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR.

Huang W, Zhang J, Wei P, Schrader WT, Moore DD. Huang W, et al. Mol Endocrinol. 2004 Oct;18(10):2402-8. doi: 10.1210/me.2004-0046. Epub 2004 Jul 22. Mol Endocrinol. 2004. PMID: 15272053

2

Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR.

Zhang J, Huang W, Chua SS, Wei P, Moore DD. Zhang J, et al. Among authors: huang w. Science. 2002 Oct 11;298(5592):422-4. doi: 10.1126/science.1073502. Science. 2002. PMID: 12376703

3

Induction of bilirubin clearance by the constitutive androstane receptor (CAR).

Huang W, Zhang J, Chua SS, Qatanani M, Han Y, Granata R, Moore DD. Huang W, et al. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4156-61. doi: 10.1073/pnas.0630614100. Epub 2003 Mar 18. Proc Natl Acad Sci U S A. 2003. PMID: 12644704 Free PMC article.

4

Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor.

Cherrington NJ, Slitt AL, Maher JM, Zhang XX, Zhang J, Huang W, Wan YJ, Moore DD, Klaassen CD. Cherrington NJ, et al. Among authors: huang w. Drug Metab Dispos. 2003 Nov;31(11):1315-9. doi: 10.1124/dmd.31.11.1315. Drug Metab Dispos. 2003. PMID: 14570762

5

A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR.

Huang W, Zhang J, Moore DD. Huang W, et al. J Clin Invest. 2004 Jan;113(1):137-43. doi: 10.1172/JCI18385. J Clin Invest. 2004. PMID: 14702117 Free PMC article.

6

CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11.

Anakk S, Kalsotra A, Kikuta Y, Huang W, Zhang J, Staudinger JL, Moore DD, Strobel HW. Anakk S, et al. Among authors: huang w. Pharmacogenomics J. 2004;4(2):91-101. doi: 10.1038/sj.tpj.6500222. Pharmacogenomics J. 2004. PMID: 14770174

7

The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity.

Zhang J, Huang W, Qatanani M, Evans RM, Moore DD. Zhang J, et al. Among authors: huang w. J Biol Chem. 2004 Nov 19;279(47):49517-22. doi: 10.1074/jbc.M409041200. Epub 2004 Sep 8. J Biol Chem. 2004. PMID: 15358766 Free article.

8

Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor.

Huang W, Zhang J, Washington M, Liu J, Parant JM, Lozano G, Moore DD. Huang W, et al. Mol Endocrinol. 2005 Jun;19(6):1646-53. doi: 10.1210/me.2004-0520. Epub 2005 Apr 14. Mol Endocrinol. 2005. PMID: 15831521

9

Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia.

Columbano A, Ledda-Columbano GM, Pibiri M, Cossu C, Menegazzi M, Moore DD, Huang W, Tian J, Locker J. Columbano A, et al. Among authors: huang w. Hepatology. 2005 Nov;42(5):1118-26. doi: 10.1002/hep.20883. Hepatology. 2005. PMID: 16231353

10

trans-Stilbene oxide induces expression of genes involved in metabolism and transport in mouse liver via CAR and Nrf2 transcription factors.

Slitt AL, Cherrington NJ, Dieter MZ, Aleksunes LM, Scheffer GL, Huang W, Moore DD, Klaassen CD. Slitt AL, et al. Among authors: huang w. Mol Pharmacol. 2006 May;69(5):1554-63. doi: 10.1124/mol.105.014571. Epub 2006 Jan 31. Mol Pharmacol. 2006. PMID: 16449384

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