Jinsmaa Y - Search Results

1

Direct influence of C-terminally substituted amino acids in the Dmt-Tic pharmacophore on delta-opioid receptor selectivity and antagonism.

Balboni G, Salvadori S, Guerrini R, Negri L, Giannini E, Bryant SD, Jinsmaa Y, Lazarus LH. Balboni G, et al. Among authors: jinsmaa y. J Med Chem. 2004 Jul 29;47(16):4066-71. doi: 10.1021/jm040033f. J Med Chem. 2004. PMID: 15267245

2

Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore.

Balboni G, Salvadori S, Guerrini R, Negri L, Giannini E, Jinsmaa Y, Bryant SD, Lazarus LH. Balboni G, et al. Among authors: jinsmaa y. J Med Chem. 2002 Dec 5;45(25):5556-63. doi: 10.1021/jm020336e. J Med Chem. 2002. PMID: 12459023

3

Unique high-affinity synthetic mu-opioid receptor agonists with central- and systemic-mediated analgesia.

Okada Y, Tsuda Y, Fujita Y, Yokoi T, Sasaki Y, Ambo A, Konishi R, Nagata M, Salvadori S, Jinsmaa Y, Bryant SD, Lazarus LH. Okada Y, et al. Among authors: jinsmaa y. J Med Chem. 2003 Jul 17;46(15):3201-9. doi: 10.1021/jm020459z. J Med Chem. 2003. PMID: 12852751

4

Synthesis and opioid activity of N,N-dimethyl-Dmt-Tic-NH-CH(R)-R' analogues: acquisition of potent delta antagonism.

Balboni G, Salvadori S, Guerrini R, Negri L, Giannini E, Bryant SD, Jinsmaa Y, Lazarus LH. Balboni G, et al. Among authors: jinsmaa y. Bioorg Med Chem. 2003 Dec 1;11(24):5435-41. doi: 10.1016/j.bmc.2003.09.039. Bioorg Med Chem. 2003. PMID: 14642588

5

Oral bioavailability of a new class of micro-opioid receptor agonists containing 3,6-bis[Dmt-NH(CH(2))(n)]-2(1H)-pyrazinone with central-mediated analgesia.

Jinsmaa Y, Miyazaki A, Fujita Y, Li T, Fujisawa Y, Shiotani K, Tsuda Y, Yokoi T, Ambo A, Sasaki Y, Bryant SD, Lazarus LH, Okada Y. Jinsmaa Y, et al. J Med Chem. 2004 May 6;47(10):2599-610. doi: 10.1021/jm0304616. J Med Chem. 2004. PMID: 15115401

6

Development of potent bifunctional endomorphin-2 analogues with mixed mu-/delta-opioid agonist and delta-opioid antagonist properties.

Fujita Y, Tsuda Y, Li T, Motoyama T, Takahashi M, Shimizu Y, Yokoi T, Sasaki Y, Ambo A, Kita A, Jinsmaa Y, Bryant SD, Lazarus LH, Okada Y. Fujita Y, et al. Among authors: jinsmaa y. J Med Chem. 2004 Jul 1;47(14):3591-9. doi: 10.1021/jm030649p. J Med Chem. 2004. PMID: 15214786

7

Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic.

Balboni G, Salvadori S, Dal Piaz A, Bortolotti F, Argazzi R, Negri L, Lattanzi R, Bryant SD, Jinsmaa Y, Lazarus LH. Balboni G, et al. Among authors: jinsmaa y. J Med Chem. 2004 Dec 16;47(26):6541-6. doi: 10.1021/jm040128h. J Med Chem. 2004. PMID: 15588089

8

Development of potent mu-opioid receptor ligands using unique tyrosine analogues of endomorphin-2.

Li T, Fujita Y, Tsuda Y, Miyazaki A, Ambo A, Sasaki Y, Jinsmaa Y, Bryant SD, Lazarus LH, Okada Y. Li T, et al. Among authors: jinsmaa y. J Med Chem. 2005 Jan 27;48(2):586-92. doi: 10.1021/jm049384k. J Med Chem. 2005. PMID: 15658871

9

From the potent and selective mu opioid receptor agonist H-Dmt-d-Arg-Phe-Lys-NH(2) to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH.

Balboni G, Cocco MT, Salvadori S, Romagnoli R, Sasaki Y, Okada Y, Bryant SD, Jinsmaa Y, Lazarus LH. Balboni G, et al. Among authors: jinsmaa y. J Med Chem. 2005 Aug 25;48(17):5608-11. doi: 10.1021/jm0504959. J Med Chem. 2005. PMID: 16107162

10

New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif.

Li T, Shiotani K, Miyazaki A, Fujita Y, Tsuda Y, Ambo A, Sasaki Y, Jinsmaa Y, Marczak E, Bryant SD, Lazarus LH, Okada Y. Li T, et al. Among authors: jinsmaa y. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5517-20. doi: 10.1016/j.bmcl.2005.08.073. Epub 2005 Sep 23. Bioorg Med Chem Lett. 2005. PMID: 16183273

These compounds represent the prototype for a new class of structural homologues lacking mu-opioid receptor-associated agonism (IC(50)=1.6-5.8muM) based on the framework of bis-[H-Dmt-NH]-alkyl (Okada, Y.; Tsuda, Y.; Fujita, Y.; Yokoi, T.; Sasaki, Y.; …

These compounds represent the prototype for a new class of structural homologues lacking mu-opioid receptor-associated agonism (IC(50)=1.6-5 …

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