Blumberg PM - Search Results

1

Macrocyclic diacylglycerol-bis-lactones as conformationally constrained analogues of diacylglycerol-lactones. Interactions with protein kinase C.

Kang JH, Kim SY, Lee J, Marquez VE, Lewin NE, Pearce LV, Blumberg PM. Kang JH, et al. Among authors: blumberg pm. J Med Chem. 2004 Jul 29;47(16):4000-7. doi: 10.1021/jm0497747. J Med Chem. 2004. PMID: 15267238

2

Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).

Sigano DM, Peach ML, Nacro K, Choi Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Sigano DM, et al. Among authors: blumberg pm. J Med Chem. 2003 Apr 24;46(9):1571-9. doi: 10.1021/jm020476o. J Med Chem. 2003. PMID: 12699375

3

Conformationally constrained analogues of diacylglycerol (DAG). Effect on protein kinase C (PK-C) binding by the isosteric replacement of sn-1 and sn-2 esters in DAG-lactones.

Kang JH, Chung HE, Kim SY, Kim Y, Lee J, Lewin NE, Pearce LV, Blumberg PM, Marquez VE. Kang JH, et al. Among authors: blumberg pm. Bioorg Med Chem. 2003 Jun 12;11(12):2529-39. doi: 10.1016/s0968-0896(03)00156-1. Bioorg Med Chem. 2003. PMID: 12757721

4

Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain.

Choi Y, Kang JH, Lewin NE, Blumberg PM, Lee J, Marquez VE. Choi Y, et al. Among authors: blumberg pm. J Med Chem. 2003 Jun 19;46(13):2790-3. doi: 10.1021/jm030082c. J Med Chem. 2003. PMID: 12801241

5

N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor.

Lee J, Lee J, Kang M, Shin M, Kim JM, Kang SU, Lim JO, Choi HK, Suh YG, Park HG, Oh U, Kim HD, Park YH, Ha HJ, Kim YH, Toth A, Wang Y, Tran R, Pearce LV, Lundberg DJ, Blumberg PM. Lee J, et al. Among authors: blumberg pm. J Med Chem. 2003 Jul 3;46(14):3116-26. doi: 10.1021/jm030089u. J Med Chem. 2003. PMID: 12825950

6

New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity.

Sridhar J, Wei ZL, Nowak I, Lewin NE, Ayres JA, Pearce LV, Blumberg PM, Kozikowski AP. Sridhar J, et al. Among authors: blumberg pm. J Med Chem. 2003 Sep 11;46(19):4196-204. doi: 10.1021/jm0302041. J Med Chem. 2003. PMID: 12954072

7

N-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: analysis of structure-activity relationships for the "C-Region".

Lee J, Kang SU, Lim JO, Choi HK, Jin MK, Toth A, Pearce LV, Tran R, Wang Y, Szabo T, Blumberg PM. Lee J, et al. Among authors: blumberg pm. Bioorg Med Chem. 2004 Jan 15;12(2):371-85. doi: 10.1016/j.bmc.2003.10.047. Bioorg Med Chem. 2004. PMID: 14723956

8

Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C through relocation of the carbonyl pharmacophore along the sn-1 side chain of 1,2-diacylglycerol lactones.

Tamamura H, Sigano DM, Lewin NE, Blumberg PM, Marquez VE. Tamamura H, et al. Among authors: blumberg pm. J Med Chem. 2004 Jan 29;47(3):644-55. doi: 10.1021/jm030454h. J Med Chem. 2004. PMID: 14736244

9

Structure-activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding.

Lee J, Kim SY, Park S, Lim JO, Kim JM, Kang M, Lee J, Kang SU, Choi HK, Jin MK, Welter JD, Szabo T, Tran R, Pearce LV, Toth A, Blumberg PM. Lee J, et al. Among authors: blumberg pm. Bioorg Med Chem. 2004 Mar 1;12(5):1055-69. doi: 10.1016/j.bmc.2003.12.005. Bioorg Med Chem. 2004. PMID: 14980619

10

Conformationally constrained diacylglycerol (DAG) analogs: 4-C-hydroxyethyl-5-O-acyl-2,3-dideoxy-D-glyceropentono-1,4-lactone analogs as protein kinase C (PKC) ligands.

Lee J, Kim SY, Kang JH, Acs G, Acs P, Blumberg PM, Marquez VE. Lee J, et al. Among authors: blumberg pm. Eur J Med Chem. 2004 Jan;39(1):69-77. doi: 10.1016/j.ejmech.2003.10.006. Eur J Med Chem. 2004. PMID: 14987835

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