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The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR).
Burk O, Koch I, Raucy J, Hustert E, Eichelbaum M, Brockmöller J, Zanger UM, Wojnowski L. Burk O, et al. Among authors: wojnowski l. J Biol Chem. 2004 Sep 10;279(37):38379-85. doi: 10.1074/jbc.M404949200. Epub 2004 Jul 12. J Biol Chem. 2004. PMID: 15252010 Free article.
Cytochrome P450 3A and their regulation.
Burk O, Wojnowski L. Burk O, et al. Among authors: wojnowski l. Naunyn Schmiedebergs Arch Pharmacol. 2004 Jan;369(1):105-24. doi: 10.1007/s00210-003-0815-3. Epub 2003 Oct 21. Naunyn Schmiedebergs Arch Pharmacol. 2004. PMID: 14569421 Review.
Contribution of CYP3A5 to the in vitro hepatic clearance of tacrolimus.
Kamdem LK, Streit F, Zanger UM, Brockmöller J, Oellerich M, Armstrong VW, Wojnowski L. Kamdem LK, et al. Among authors: wojnowski l. Clin Chem. 2005 Aug;51(8):1374-81. doi: 10.1373/clinchem.2005.050047. Epub 2005 Jun 10. Clin Chem. 2005. PMID: 15951320
118 results