Humblet C - Search Results

1

X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors.

Cooper J, Quail W, Frazao C, Foundling SI, Blundell TL, Humblet C, Lunney EA, Lowther WT, Dunn BM. Cooper J, et al. Among authors: humblet c. Biochemistry. 1992 Sep 8;31(35):8142-50. doi: 10.1021/bi00150a005. Biochemistry. 1992. PMID: 1525155

2

Analysis of the binding of hydroxamic acid and carboxylic acid inhibitors to the stromelysin-1 (matrix metalloproteinase-3) catalytic domain by isothermal titration calorimetry.

Parker MH, Lunney EA, Ortwine DF, Pavlovsky AG, Humblet C, Brouillette CG. Parker MH, et al. Among authors: humblet c. Biochemistry. 1999 Oct 12;38(41):13592-601. doi: 10.1021/bi991222g. Biochemistry. 1999. PMID: 10521266

3

X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.

Cronin NB, Badasso MO, J Tickle I, Dreyer T, Hoover DJ, Rosati RL, Humblet CC, Lunney EA, Cooper JB. Cronin NB, et al. Among authors: humblet cc. J Mol Biol. 2000 Nov 10;303(5):745-60. doi: 10.1006/jmbi.2000.4181. J Mol Biol. 2000. PMID: 11061973

4

X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily.

Dhanaraj V, Ye QZ, Johnson LL, Hupe DJ, Ortwine DF, Dunbar JB Jr, Rubin JR, Pavlovsky A, Humblet C, Blundell TL. Dhanaraj V, et al. Among authors: humblet c. Structure. 1996 Apr 15;4(4):375-86. doi: 10.1016/s0969-2126(96)00043-3. Structure. 1996. PMID: 8740360 Free article.

5

Molecular modeling of renin inhibitor P2 substituents.

Lunney EA, Humblet CC, Repine JT, Blundell TL, Cooper JB, Sibanda BL. Lunney EA, et al. Among authors: humblet cc. Adv Exp Med Biol. 1991;306:391-4. doi: 10.1007/978-1-4684-6012-4_51. Adv Exp Med Biol. 1991. PMID: 1812735 No abstract available.

6

Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation.

Rao CM, Scarborough PE, Kay J, Batley B, Rapundalo S, Klutchko S, Taylor MD, Lunney EA, Humblet CC, Dunn BM. Rao CM, et al. Among authors: humblet cc. J Med Chem. 1993 Sep 3;36(18):2614-20. doi: 10.1021/jm00070a004. J Med Chem. 1993. PMID: 8410973

7

Designing inhibitors of the metalloproteinase superfamily: comparative analysis of representative structures.

Dhanaraj V, Ye QZ, Johnson LL, Hupe DJ, Ortwine DF, Dunbar JB Jr, Rubin JR, Pavlovsky A, Humblet C, Blundell TL. Dhanaraj V, et al. Among authors: humblet c. Drug Des Discov. 1996 Apr;13(3-4):3-14. Drug Des Discov. 1996. PMID: 8874040

8

Design and synthesis of renin inhibitors: incorporation of transition-state isostere side chains that span from the S1 to the S3 binding pockets and examination of P3-modified renin inhibitors.

Plummer MS, Shahripour A, Kaltenbronn JS, Lunney EA, Steinbaugh BA, Hamby JM, Hamilton HW, Sawyer TK, Humblet C, Doherty AM, et al. Plummer MS, et al. Among authors: humblet c. J Med Chem. 1995 Jul 21;38(15):2893-905. doi: 10.1021/jm00015a012. J Med Chem. 1995. PMID: 7636850

9

Design, synthesis and solution structure of a renin inhibitor. Structural constraints from NOE, and homonuclear and heteronuclear coupling constants combined with distance geometry calculations.

Reily MD, Thanabal V, Lunney EA, Repine JT, Humblet CC, Wagner G. Reily MD, et al. Among authors: humblet cc. FEBS Lett. 1992 May 4;302(1):97-103. doi: 10.1016/0014-5793(92)80293-p. FEBS Lett. 1992. PMID: 1587361 Free article.

10

Renin inhibitors containing alpha-heteroatom amino acids as P2 residues.

Repine JT, Kaltenbronn JS, Doherty AM, Hamby JM, Himmelsbach RJ, Kornberg BE, Taylor MD, Lunney EA, Humblet C, Rapundalo ST, et al. Repine JT, et al. Among authors: humblet c. J Med Chem. 1992 Mar 20;35(6):1032-42. doi: 10.1021/jm00084a008. J Med Chem. 1992. PMID: 1552498

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