Bierbach U - Search Results

1

Unique base-step recognition by a platinum-acridinylthiourea conjugate leads to a DNA damage profile complementary to that of the anticancer drug cisplatin.

Budiman ME, Alexander RW, Bierbach U. Budiman ME, et al. Among authors: bierbach u. Biochemistry. 2004 Jul 6;43(26):8560-7. doi: 10.1021/bi049415d. Biochemistry. 2004. PMID: 15222767

2

Mechanism of action of non-cisplatin type DNA-targeted platinum anticancer agents: DNA interactions of novel acridinylthioureas and their platinum conjugates.

Baruah H, Rector CL, Monnier SM, Bierbach U. Baruah H, et al. Among authors: bierbach u. Biochem Pharmacol. 2002 Jul 15;64(2):191-200. doi: 10.1016/s0006-2952(02)01107-3. Biochem Pharmacol. 2002. PMID: 12123739

3

Cytotoxic acridinylthiourea and its platinum conjugate produce enzyme-mediated DNA strand breaks.

Brow JM, Pleatman CR, Bierbach U. Brow JM, et al. Among authors: bierbach u. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2953-5. doi: 10.1016/s0960-894x(02)00620-0. Bioorg Med Chem Lett. 2002. PMID: 12270182

4

Bis(acridinylthiourea)platinum(II) complexes: synthesis, DNA affinity, and biological activity in glioblastoma cells.

Augustus TM, Anderson J, Hess SM, Bierbach U. Augustus TM, et al. Among authors: bierbach u. Bioorg Med Chem Lett. 2003 Mar 10;13(5):855-8. doi: 10.1016/s0960-894x(02)01078-8. Bioorg Med Chem Lett. 2003. PMID: 12617907

5

Unusual intercalation of acridin-9-ylthiourea into the 5'-GA/TC DNA base step from the minor groove: implications for the covalent DNA adduct profile of a novel platinum-intercalator conjugate.

Baruah H, Bierbach U. Baruah H, et al. Among authors: bierbach u. Nucleic Acids Res. 2003 Jul 15;31(14):4138-46. doi: 10.1093/nar/gkg465. Nucleic Acids Res. 2003. PMID: 12853631 Free PMC article.

6

Biophysical characterization and molecular modeling of the coordinative-intercalative DNA monoadduct of a platinum-acridinylthiourea agent in a site-specifically modified dodecamer.

Baruah H, Bierbach U. Baruah H, et al. Among authors: bierbach u. J Biol Inorg Chem. 2004 Apr;9(3):335-44. doi: 10.1007/s00775-004-0534-3. Epub 2004 Mar 16. J Biol Inorg Chem. 2004. PMID: 15024635

7

Structure-activity relationships in platinum-acridinylthiourea conjugates: effect of the thiourea nonleaving group on drug stability, nucleobase affinity, and in vitro cytotoxicity.

Ackley MC, Barry CG, Mounce AM, Farmer MC, Springer BE, Day CS, Wright MW, Berners-Price SJ, Hess SM, Bierbach U. Ackley MC, et al. Among authors: bierbach u. J Biol Inorg Chem. 2004 Jun;9(4):453-61. doi: 10.1007/s00775-004-0541-4. Epub 2004 Apr 6. J Biol Inorg Chem. 2004. PMID: 15067524

8

Metal-intercalator-mediated self-association and one-dimensional aggregation in the structure of the excised major DNA adduct of a platinum-acridine agent.

Baruah H, Day CS, Wright MW, Bierbach U. Baruah H, et al. Among authors: bierbach u. J Am Chem Soc. 2004 Apr 14;126(14):4492-3. doi: 10.1021/ja038592j. J Am Chem Soc. 2004. PMID: 15070347

9

Platinum-intercalator conjugates: from DNA-targeted cisplatin derivatives to adenine binding complexes as potential modulators of gene regulation.

Baruah H, Barry CG, Bierbach U. Baruah H, et al. Among authors: bierbach u. Curr Top Med Chem. 2004;4(15):1537-49. doi: 10.2174/1568026043387313. Curr Top Med Chem. 2004. PMID: 15579095 Review.

10

A non-crosslinking platinum-acridine hybrid agent shows enhanced cytotoxicity compared to clinical BCNU and cisplatin in glioblastoma cells.

Hess SM, Anderson JG, Bierbach U. Hess SM, et al. Among authors: bierbach u. Bioorg Med Chem Lett. 2005 Jan 17;15(2):443-6. doi: 10.1016/j.bmcl.2004.10.049. Bioorg Med Chem Lett. 2005. PMID: 15603970

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