Barril X - Search Results

1

Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms.

Wright L, Barril X, Dymock B, Sheridan L, Surgenor A, Beswick M, Drysdale M, Collier A, Massey A, Davies N, Fink A, Fromont C, Aherne W, Boxall K, Sharp S, Workman P, Hubbard RE. Wright L, et al. Among authors: barril x. Chem Biol. 2004 Jun;11(6):775-85. doi: 10.1016/j.chembiol.2004.03.033. Chem Biol. 2004. PMID: 15217611

2

Multi-Responsive Eight-State Bis(acridinium-Zn(II) porphyrin) Receptor.

Edo-Osagie A, Serillon D, Ruani F, Barril X, Gourlaouen C, Armaroli N, Ventura B, Jacquot de Rouville HP, Heitz V. Edo-Osagie A, et al. Among authors: barril x. J Am Chem Soc. 2023 May 17;145(19):10691-10699. doi: 10.1021/jacs.3c01089. Epub 2023 May 8. J Am Chem Soc. 2023. PMID: 37154483 Free PMC article.

3

Validation of a highly sensitive HaloTag-based assay to evaluate the potency of a novel class of allosteric β-Galactosidase correctors.

Rudinskiy M, Pons-Vizcarra M, Soldà T, Fregno I, Bergmann TJ, Ruano A, Delgado A, Morales S, Barril X, Bellotto M, Cubero E, García-Collazo AM, Pérez-Carmona N, Molinari M. Rudinskiy M, et al. Among authors: barril x. PLoS One. 2023 Nov 29;18(11):e0294437. doi: 10.1371/journal.pone.0294437. eCollection 2023. PLoS One. 2023. PMID: 38019733 Free PMC article.

4

Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures.

Dymock B, Barril X, Beswick M, Collier A, Davies N, Drysdale M, Fink A, Fromont C, Hubbard RE, Massey A, Surgenor A, Wright L. Dymock B, et al. Among authors: barril x. Bioorg Med Chem Lett. 2004 Jan 19;14(2):325-8. doi: 10.1016/j.bmcl.2003.11.011. Bioorg Med Chem Lett. 2004. PMID: 14698151

5

Virtual screening in structure-based drug discovery.

Barril X, Hubbard RE, Morley SD. Barril X, et al. Mini Rev Med Chem. 2004 Sep;4(7):779-91. doi: 10.2174/1389557043403675. Mini Rev Med Chem. 2004. PMID: 15379645 Review.

6

Design and characterization of libraries of molecular fragments for use in NMR screening against protein targets.

Baurin N, Aboul-Ela F, Barril X, Davis B, Drysdale M, Dymock B, Finch H, Fromont C, Richardson C, Simmonite H, Hubbard RE. Baurin N, et al. Among authors: barril x. J Chem Inf Comput Sci. 2004 Nov-Dec;44(6):2157-66. doi: 10.1021/ci049806z. J Chem Inf Comput Sci. 2004. PMID: 15554686

7

Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.

Dymock BW, Barril X, Brough PA, Cansfield JE, Massey A, McDonald E, Hubbard RE, Surgenor A, Roughley SD, Webb P, Workman P, Wright L, Drysdale MJ. Dymock BW, et al. Among authors: barril x. J Med Chem. 2005 Jun 30;48(13):4212-5. doi: 10.1021/jm050355z. J Med Chem. 2005. PMID: 15974572

8

Unveiling the full potential of flexible receptor docking using multiple crystallographic structures.

Barril X, Morley SD. Barril X, et al. J Med Chem. 2005 Jun 30;48(13):4432-43. doi: 10.1021/jm048972v. J Med Chem. 2005. PMID: 15974595

9

Structure-based discovery of a new class of Hsp90 inhibitors.

Barril X, Brough P, Drysdale M, Hubbard RE, Massey A, Surgenor A, Wright L. Barril X, et al. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5187-91. doi: 10.1016/j.bmcl.2005.08.092. Epub 2005 Oct 3. Bioorg Med Chem Lett. 2005. PMID: 16202589

10

3-(5-Chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone.

Brough PA, Barril X, Beswick M, Dymock BW, Drysdale MJ, Wright L, Grant K, Massey A, Surgenor A, Workman P. Brough PA, et al. Among authors: barril x. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5197-201. doi: 10.1016/j.bmcl.2005.08.091. Epub 2005 Oct 5. Bioorg Med Chem Lett. 2005. PMID: 16213716

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