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Page 1
Hydrophobic acetal and ketal derivatives of mannopeptimycin-alpha and desmethylhexahydromannopeptimycin-alpha: semisynthetic glycopeptides with potent activity against Gram-positive bacteria.
Dushin RG, Wang TZ, Sum PE, He H, Sutherland AG, Ashcroft JS, Graziani EI, Koehn FE, Bradford PA, Petersen PJ, Wheless KL, How D, Torres N, Lenoy EB, Weiss WJ, Lang SA, Projan SJ, Shlaes DM, Mansour TS. Dushin RG, et al. Among authors: shlaes dm. J Med Chem. 2004 Jul 1;47(14):3487-90. doi: 10.1021/jm049765y. J Med Chem. 2004. PMID: 15214775
Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.
Venkatesan AM, Agarwal A, Abe T, Ushirogochi H, Yamamura I, Ado M, Tsuyoshi T, Dos Santos O, Gu Y, Sum FW, Li Z, Francisco G, Lin YI, Petersen PJ, Yang Y, Kumagai T, Weiss WJ, Shlaes DM, Knox JR, Mansour TS. Venkatesan AM, et al. Among authors: shlaes dm. J Med Chem. 2006 Jul 27;49(15):4623-37. doi: 10.1021/jm060021p. J Med Chem. 2006. PMID: 16854068
5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases.
Venkatesan AM, Agarwal A, Abe T, Ushirogochi H, Ado M, Tsuyoshi T, Dos Santos O, Li Z, Francisco G, Lin YI, Petersen PJ, Yang Y, Weiss WJ, Shlaes DM, Mansour TS. Venkatesan AM, et al. Among authors: shlaes dm. Bioorg Med Chem. 2008 Feb 15;16(4):1890-902. doi: 10.1016/j.bmc.2007.11.006. Epub 2007 Nov 5. Bioorg Med Chem. 2008. PMID: 18061461
Mechanism of action of the mannopeptimycins, a novel class of glycopeptide antibiotics active against vancomycin-resistant gram-positive bacteria.
Ruzin A, Singh G, Severin A, Yang Y, Dushin RG, Sutherland AG, Minnick A, Greenstein M, May MK, Shlaes DM, Bradford PA. Ruzin A, et al. Among authors: shlaes dm. Antimicrob Agents Chemother. 2004 Mar;48(3):728-38. doi: 10.1128/AAC.48.3.728-738.2004. Antimicrob Agents Chemother. 2004. PMID: 14982757 Free PMC article.
3,5-dioxopyrazolidines, novel inhibitors of UDP-N- acetylenolpyruvylglucosamine reductase (MurB) with activity against gram-positive bacteria.
Yang Y, Severin A, Chopra R, Krishnamurthy G, Singh G, Hu W, Keeney D, Svenson K, Petersen PJ, Labthavikul P, Shlaes DM, Rasmussen BA, Failli AA, Shumsky JS, Kutterer KM, Gilbert A, Mansour TS. Yang Y, et al. Among authors: shlaes dm. Antimicrob Agents Chemother. 2006 Feb;50(2):556-64. doi: 10.1128/AAC.50.2.556-564.2006. Antimicrob Agents Chemother. 2006. PMID: 16436710 Free PMC article.
Antibacterial drug discovery: is it all downhill from here?
Projan SJ, Shlaes DM. Projan SJ, et al. Among authors: shlaes dm. Clin Microbiol Infect. 2004 Nov;10 Suppl 4:18-22. doi: 10.1111/j.1465-0691.2004.1006.x. Clin Microbiol Infect. 2004. PMID: 15522036 Free article. Review.
133 results