Discafani C - Search Results

1

Identification of 4-anilino-3-quinolinecarbonitrile inhibitors of mitogen-activated protein/extracellular signal-regulated kinase 1 kinase.

Mallon R, Feldberg L, Kim S, Collins K, Wojciechowicz D, Kohler C, Kovacs D, Discafani C, Zhang N, Wu B, Floyd B, Powell D, Berger D. Mallon R, et al. Among authors: discafani c. Mol Cancer Ther. 2004 Jun;3(6):755-62. Mol Cancer Ther. 2004. PMID: 15210862

2

Synthesis and evaluation of 4-anilino-6,7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade.

Berger D, Dutia M, Powell D, Wu B, Wissner A, Boschelli DH, Floyd MB, Zhang N, Torres N, Levin J, Du X, Wojciechowicz D, Discafani C, Kohler C, Kim SC, Feldberg LR, Collins K, Mallon R. Berger D, et al. Among authors: discafani c. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3031-4. doi: 10.1016/s0960-894x(03)00640-1. Bioorg Med Chem Lett. 2003. PMID: 12941327

3

TTI-237: a novel microtubule-active compound with in vivo antitumor activity.

Beyer CF, Zhang N, Hernandez R, Vitale D, Lucas J, Nguyen T, Discafani C, Ayral-Kaloustian S, Gibbons JJ. Beyer CF, et al. Among authors: discafani c. Cancer Res. 2008 Apr 1;68(7):2292-300. doi: 10.1158/0008-5472.CAN-07-1420. Cancer Res. 2008. PMID: 18381436

4

Synthesis, SAR study and biological evaluation of novel pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as anti-proliferative agents.

Wang YD, Honores E, Wu B, Johnson S, Powell D, Miranda M, McGinnis JP, Discafani C, Rabindran SK, Cheng W, Krishnamurthy G. Wang YD, et al. Among authors: discafani c. Bioorg Med Chem. 2009 Mar 1;17(5):2091-100. doi: 10.1016/j.bmc.2008.12.046. Epub 2008 Dec 25. Bioorg Med Chem. 2009. PMID: 19200741

5

Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity.

Boschelli DH, Ye F, Wang YD, Dutia M, Johnson SL, Wu B, Miller K, Powell DW, Yaczko D, Young M, Tischler M, Arndt K, Discafani C, Etienne C, Gibbons J, Grod J, Lucas J, Weber JM, Boschelli F. Boschelli DH, et al. Among authors: discafani c. J Med Chem. 2001 Nov 8;44(23):3965-77. doi: 10.1021/jm0102250. J Med Chem. 2001. PMID: 11689083

6

Synthesis and SAR of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents.

Zhang N, Ayral-Kaloustian S, Nguyen T, Hernandez R, Lucas J, Discafani C, Beyer C. Zhang N, et al. Among authors: discafani c. Bioorg Med Chem. 2009 Jan 1;17(1):111-8. doi: 10.1016/j.bmc.2008.11.016. Epub 2008 Nov 14. Bioorg Med Chem. 2009. PMID: 19041247

7

Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase.

Rabindran SK, Discafani CM, Rosfjord EC, Baxter M, Floyd MB, Golas J, Hallett WA, Johnson BD, Nilakantan R, Overbeek E, Reich MF, Shen R, Shi X, Tsou HR, Wang YF, Wissner A. Rabindran SK, et al. Among authors: discafani cm. Cancer Res. 2004 Jun 1;64(11):3958-65. doi: 10.1158/0008-5472.CAN-03-2868. Cancer Res. 2004. PMID: 15173008

8

MAC-321, a novel taxane with greater efficacy than paclitaxel and docetaxel in vitro and in vivo.

Sampath D, Discafani CM, Loganzo F, Beyer C, Liu H, Tan X, Musto S, Annable T, Gallagher P, Rios C, Greenberger LM. Sampath D, et al. Among authors: discafani cm. Mol Cancer Ther. 2003 Sep;2(9):873-84. Mol Cancer Ther. 2003. PMID: 14555706

9

SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models.

Golas JM, Lucas J, Etienne C, Golas J, Discafani C, Sridharan L, Boghaert E, Arndt K, Ye F, Boschelli DH, Li F, Titsch C, Huselton C, Chaudhary I, Boschelli F. Golas JM, et al. Among authors: discafani c. Cancer Res. 2005 Jun 15;65(12):5358-64. doi: 10.1158/0008-5472.CAN-04-2484. Cancer Res. 2005. PMID: 15958584

10

HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

Loganzo F, Discafani CM, Annable T, Beyer C, Musto S, Hari M, Tan X, Hardy C, Hernandez R, Baxter M, Singanallore T, Khafizova G, Poruchynsky MS, Fojo T, Nieman JA, Ayral-Kaloustian S, Zask A, Andersen RJ, Greenberger LM. Loganzo F, et al. Among authors: discafani cm. Cancer Res. 2003 Apr 15;63(8):1838-45. Cancer Res. 2003. PMID: 12702571

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