Barrett MP - Search Results

1

Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues.

Dardonville C, Rinaldi E, Barrett MP, Brun R, Gilbert IH, Hanau S. Dardonville C, et al. Among authors: barrett mp. J Med Chem. 2004 Jun 17;47(13):3427-37. doi: 10.1021/jm031066i. J Med Chem. 2004. PMID: 15189039

2

6-phosphogluconate dehydrogenase: a target for drugs in African trypanosomes.

Hanau S, Rinaldi E, Dallocchio F, Gilbert IH, Dardonville C, Adams MJ, Gover S, Barrett MP. Hanau S, et al. Among authors: barrett mp. Curr Med Chem. 2004 Oct;11(19):2639-50. doi: 10.2174/0929867043364441. Curr Med Chem. 2004. PMID: 15544466 Review.

3

Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites.

Baliani A, Bueno GJ, Stewart ML, Yardley V, Brun R, Barrett MP, Gilbert IH. Baliani A, et al. Among authors: barrett mp. J Med Chem. 2005 Aug 25;48(17):5570-9. doi: 10.1021/jm050177+. J Med Chem. 2005. PMID: 16107157

4

Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase.

Ruda GF, Campbell G, Alibu VP, Barrett MP, Brenk R, Gilbert IH. Ruda GF, et al. Among authors: barrett mp. Bioorg Med Chem. 2010 Jul 15;18(14):5056-62. doi: 10.1016/j.bmc.2010.05.077. Epub 2010 Jun 9. Bioorg Med Chem. 2010. PMID: 20598892 Free PMC article.

5

Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis.

Dardonville C, Rinaldi E, Hanau S, Barrett MP, Brun R, Gilbert IH. Dardonville C, et al. Among authors: barrett mp. Bioorg Med Chem. 2003 Jul 17;11(14):3205-14. doi: 10.1016/s0968-0896(03)00191-3. Bioorg Med Chem. 2003. PMID: 12818683

6

Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs.

Klenke B, Stewart M, Barrett MP, Brun R, Gilbert IH. Klenke B, et al. Among authors: barrett mp. J Med Chem. 2001 Oct 11;44(21):3440-52. doi: 10.1021/jm010854+. J Med Chem. 2001. PMID: 11585449

7

An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes.

Tye CK, Kasinathan G, Barrett MP, Brun R, Doyle VE, Fairlamb AH, Weaver R, Gilbert IH. Tye CK, et al. Among authors: barrett mp. Bioorg Med Chem Lett. 1998 Apr 7;8(7):811-6. doi: 10.1016/s0960-894x(98)00095-x. Bioorg Med Chem Lett. 1998. PMID: 9871546

8

Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporter.

Stewart ML, Boussard C, Brun R, Gilbert IH, Barrett MP. Stewart ML, et al. Among authors: barrett mp. Antimicrob Agents Chemother. 2005 Dec;49(12):5169-71. doi: 10.1128/AAC.49.12.5169-5171.2005. Antimicrob Agents Chemother. 2005. PMID: 16304196 Free PMC article.

9

DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity.

Dardonville C, Barrett MP, Brun R, Kaiser M, Tanious F, Wilson WD. Dardonville C, et al. Among authors: barrett mp. J Med Chem. 2006 Jun 15;49(12):3748-52. doi: 10.1021/jm060295c. J Med Chem. 2006. PMID: 16759117 Free article.

10

Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates.

Sundaramoorthy R, Iulek J, Barrett MP, Bidet O, Ruda GF, Gilbert IH, Hunter WN. Sundaramoorthy R, et al. Among authors: barrett mp. FEBS J. 2007 Jan;274(1):275-86. doi: 10.1111/j.1742-4658.2006.05585.x. FEBS J. 2007. PMID: 17222187 Free PMC article.

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