Hoelzer D - Search Results

1

In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors.

Brieger A, Boehrer S, Schaaf S, Nowak D, Ruthardt M, Kim SZ, Atadja P, Hoelzer D, Mitrou PS, Weidmann E, Chow KU. Brieger A, et al. Among authors: hoelzer d. Biochem Pharmacol. 2004 Jul 1;68(1):85-93. doi: 10.1016/j.bcp.2004.02.028. Biochem Pharmacol. 2004. PMID: 15183120

2

Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation.

Chow KU, Nowak D, Boehrer S, Ruthardt M, Knau A, Hoelzer D, Mitrou PS, Weidmann E. Chow KU, et al. Among authors: hoelzer d. Biochem Pharmacol. 2003 Sep 1;66(5):711-24. doi: 10.1016/s0006-2952(03)00410-6. Biochem Pharmacol. 2003. PMID: 12948851

3

Prostate apoptosis response gene-4 (par-4) abrogates the survival function of p185(BCR-ABL) in hematopoietic cells.

Kukoc-Zivojnov N, Puccetti E, Chow KU, Bergmann M, Ruthardt M, Hoelzer D, Mitrou PS, Weidmann E, Boehrer S. Kukoc-Zivojnov N, et al. Among authors: hoelzer d. Exp Hematol. 2004 Jul;32(7):649-56. doi: 10.1016/j.exphem.2004.04.004. Exp Hematol. 2004. PMID: 15246161 Free article.

4

Prostate apoptosis response gene-4 sensitizes neoplastic lymphocytes to CD95-induced apoptosis.

Bergmann M, Kukoc-Zivojnov N, Chow KU, Trepohl B, Hoelzer D, Weidmann E, Mitrou PS, Boehrer S. Bergmann M, et al. Among authors: hoelzer d. Ann Hematol. 2004 Oct;83(10):646-53. doi: 10.1007/s00277-004-0922-3. Epub 2004 Aug 14. Ann Hematol. 2004. PMID: 15316756

5

In the erythroleukemic cell line HEL Prostate-apoptosis-response-gene-4 (par-4) fails to down-regulate Bcl-2 and to promote apoptosis.

Boehrer S, Brieger A, Schaaf S, Kukoc-Zivojnov N, Nowak D, Ruthardt M, Hoelzer D, Mitrou PS, Weidmann E, Chow KU. Boehrer S, et al. Among authors: hoelzer d. Leuk Lymphoma. 2004 Jul;45(7):1445-51. doi: 10.1080/10428190410001663617. Leuk Lymphoma. 2004. PMID: 15359646

6

In malignant myeloid cells expression of Daxx downregulates expression of p53 and of the inhibitors of apoptosis proteins.

Boehrer S, Nowak D, Schaaf S, Bergmann M, Brieger A, Hoelzer D, Mitrou PS, Weidmann E, Chow KU. Boehrer S, et al. Among authors: hoelzer d. Hematol J. 2004;5(6):513-8. doi: 10.1038/sj.thj.6200547. Hematol J. 2004. PMID: 15570294

7

Daxx overexpression in T-lymphoblastic Jurkat cells enhances caspase-dependent death receptor- and drug-induced apoptosis in distinct ways.

Boehrer S, Nowak D, Hochmuth S, Kim SZ, Trepohl B, Afkir A, Hoelzer D, Mitrou PS, Weidmann E, Chow KU. Boehrer S, et al. Among authors: hoelzer d. Cell Signal. 2005 May;17(5):581-95. doi: 10.1016/j.cellsig.2004.09.014. Cell Signal. 2005. PMID: 15683733

8

Expression of Daxx sensitizes Jurkat T-cells to the apoptosis-inducing effect of chemotherapeutic agents.

Boehrer S, Nowak D, Kukoc-Zivojnov N, Hochmuth S, Kim SZ, Hoelzer D, Mitrou PS, Weidmann E, Chow KU. Boehrer S, et al. Among authors: hoelzer d. Pharmacol Res. 2005 Apr;51(4):367-74. doi: 10.1016/j.phrs.2004.10.011. Pharmacol Res. 2005. PMID: 15683751

9

Upon drug-induced apoptosis expression of prostate-apoptosis-response-gene-4 promotes cleavage of caspase-8, bid and mitochondrial release of cytochrome c.

Boehrer S, Kukoc-Zivojnov N, Nowak D, Bergmann M, Baum C, Puccetti E, Weidmann E, Hoelzer D, Mitrou PS, Chow KU. Boehrer S, et al. Among authors: hoelzer d. Hematology. 2004 Oct-Dec;9(5-6):425-31. doi: 10.1080/10245330400010604. Hematology. 2004. PMID: 15763985 Free article.

10

Novel agents aiming at specific molecular targets increase chemosensitivity and overcome chemoresistance in hematopoietic malignancies.

Boehrer S, Nowak D, Hoelzer D, Mitrou PS, Chow KU. Boehrer S, et al. Among authors: hoelzer d. Curr Pharm Des. 2006;12(1):111-28. doi: 10.2174/138161206780574588. Curr Pharm Des. 2006. PMID: 16454729 Review.

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